Prospective Study
Copyright
©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Diabetes. Jul 15, 2022; 13(7): 566-580
Published online Jul 15, 2022. doi: 10.4239/wjd.v13.i7.566
Table 1 General characteristics of glycolipid metabolism study in adolescents (mean ± SD)
Variable Male Female F P value Anthropometric measures Age, yr 11.21 ± 0.64 11.13 ± 0.68 7.55 0.006 Height, cm 151.52 ± 8.53 152.08 ± 7.30 2.41 0.121 Weight, kg 45.31 ± 11.87 43.46 ± 10.00 13.81 < 0.001 Waist circumference, cm 68.17 ± 11.07 63.76 ± 8.52 96.30 < 0.001 FBG, mmol/L 4.49 ± 0.45 4.42 ± 0.41 14.81 < 0.001 HbA1c, % 5.37 ± 0.20 5.37 ± 0.19 0.04 0.843 Insulin, pmol/L 82.91 ± 81.09 85.30 ± 70.01 0.48 0.486 Insulin resistance index 2.42 ± 2.65 2.41 ± 2.13 0.01 0.952 Creatinine, mmol/L 52.86 ± 10.60 53.96 ± 28.20 1.26 0.261 Uric acid, μmol/L 333.51 ± 83.13 305.13 ± 66.72 65.16 < 0.001 TG, mean, mmol/L 1.04 ± 0.52 1.09 ± 0.49 4.41 0.036 HDL-C, mmol/L 1.43 ± 0.32 1.43 ± 0.30 0.00 0.994 LDL-C, mmol/L 1.84 ± 0.43 1.84 ± 0.44 0.02 0.893 Physical activity, min/day 3.52 ± 0.62 3.52 ± 0.57 0.01 0.939 Sleep score 45.08 ± 5.85 45.97± 6.38 10.36 0.001 Dietary intake, g/day Cereals and potatoes 183.48 ± 173.6 160.72 ± 164.5 8.86 0.003 Vegetables 207.71 ± 197.7 216.41 ± 213.8 0.88 0.349 Red meat 159.26 ± 199.9 152.11 ± 204.2 0.61 0.434 Nutritional supplements 20.05 ± 32.04 19.29 ± 32.57 0.27 0.603 Increased BMI during pregnancy, kg/m2 1.82 ± 0.75 1.82 ± 0.75 0.05 0.829 13 domains of QoL Self-satisfaction 50.83 ± 11.09 49.33 ± 11.48 8.60 0.003 Relationship of teacher and pupil 53.62 ± 10.20 53.81 ± 9.64 0.19 0.665 Physical feeling 50.32 ± 10.53 49.60 ± 11.00 2.16 0.142 Companionship 54.34 ± 9.88 53.14 ± 10.96 6.49 0.011 Parenthood 52.13 ± 10.83 50.73 ± 11.76 7.43 0.007 Physical activity ability 50.11 ± 10.96 50.13 ± 10.23 0.01 0.966 Learning ability and attitude 52.34 ± 9.92 51.41 ± 10.33 4.14 0.042 Self-esteem 51.18 ± 11.20 49.75 ± 10.84 8.21 0.004 Negative emotion 48.23 ± 10.79 47.14 ± 11.57 4.61 0.032 Attitude towards doing homework 51.44 ± 9.23 51.59 ± 9.00 0.13 0.716 Activity opportunity 54.99 ± 9.40 54.39 ± 9.64 1.88 0.170 Living convenience 54.41 ± 7.88 54.54 ± 7.47 0.14 0.704 Other 50.99 ± 10.01 50.60 ± 10.13 0.71 0.401 Four factors of QoL Psychosocial factor 64.71 ± 10.26 65.25 ± 10.17 1.36 0.244 Physical and mental health factor 36.00 ± 6.02 35.77 ± 5.90 0.73 0.393 Living environment factor 24.36 ± 4.20 23.73 ± 4.28 10.58 0.001 Quality of life satisfaction factor 25.13 ± 4.31 24.72 ± 4.42 4.38 0.037 Mother’s education, yr, n (%) Approximately 9 314 (31.15) 325 (34.17) 2.35 0.308 Approximately 12 360 (35.71) 315 (33.12) ≥ 15 334 (33.13) 311 (32.70) Father’s education, yr, n (%) Approximately 9 277 (27.48) 250 (26.29) 6.22 0.045 Approximately 12 338 (33.53) 369 (38.80) ≥ 15 393 (38.99) 332 (34.91) Income, Yuan/year, n (%) Approximately 25000 155 (15.38) 141 (14.83) 2.74 0.741 Approximately 50000 166 (16.47) 168 (17.67) Approximately 100000 236 (23.41) 245 (25.76) Approximately 150000 190 (18.85) 163 (17.14) Approximately 200000 117 (11.61) 106 (11.15) > 200000 144 (14.29) 128 (13.46) Region Urban, n (%) 764 (75.79) 728 (76.55) 0.16 0.694 Rural, n (%) 244 (24.21) 223 (23.45)
Table 2 Effect of dimensions of quality of life on glycolipid metabolism disorder
Variable FI IR TG HDL β (95%CI) P value β (95%CI) P value β (95%CI) P value β (95%CI) P value Model 1 (domains of QoL) Self-satisfaction -0.399 (-0.696, -0.102) 0.009 -0.011 (-0.021, -0.001) 0.028 -0.003 (-0.005, -0.001) 0.004 0.000 (-0.001, 0.002) 0.509 Relationship of teacher and pupil -0.272 (-0.607, 0.063) 0.112 -0.006 (-0.017, 0.005) 0.252 -0.004 (-0.006, -0.001) 0.002 0.001 (-0.000, 0.002) 0.177 Activity opportunity -0.452 (-0.761, -0.143) 0.004 -0.013 (-0.023, -0.003) 0.014 -0.003 (-0.005, -0.000) 0.017 0.001 (-0.000, 0.002) 0.098 Physical activity ability -0.608 (-0.920, -0.295) < 0.001 -0.014 (-0.024, -0.004) 0.008 -0.004 (-0.007, -0.002) < 0.001 0.002 (0.001, 0.003) 0.098 Learning ability and attitude -0.391 (-0.721, -0.061) 0.020 -0.010 (-0.021, 0.001) 0.075 -0.002 (-0.004, 0.000) 0.109 0.002 (0.001, 0.003) 0.002 Attitude towards doing homework -0.684 (-1.05, -0.319 ) <0.001 -0.018 (-0.030, -0.006) 0.003 -0.005 (-0.008, -0.003) < 0.001 0.002 (0.000, 0.003) 0.033 Living convenience -0.469 (-0.905, -0.034) 0.035 -0.016 (-0.030, -0.001) 0.030 -0.003 (-0.005, 0.000) 0.093 0.001 (-0.001, 0.003) 0.311 Model 2 (domains of QoL) Self-satisfaction -0.352 (-0.641, -0.063) 0.017 -0.009 (-0.019, 0.000) 0.054 -0.003 (-0.005, -0.001) 0.006 0.001 (-0.001, 0.002) 0.330 Relationship of teacher and pupil -0.327 (-0.646, -0.007) 0.045 -0.008 (-0.019, 0.002) 0.127 -0.003 (-0.006, -0.001) 0.003 0.001 (-0.000, 0.002) 0.203 Activity opportunity -0.421 (-0.719, -0.123) 0.006 -0.012 (-0.022, -0.002) 0.018 -0.003 (-0.005, -0.001) 0.011 0.001 (0.000, 0.003) 0.027 Physical activity ability -0.394 (-0.696, -0.091) 0.011 -0.008 (-0.018, 0.002) 0.113 -0.003 (-0.005, -0.001) 0.005 0.001 (-0.000, 0.002) 0.192 Learning ability and attitude -0.442 (-0.758, -0.126) 0.006 -0.011 (-0.021, -0.000) 0.046 -0.001 (-0.004, 0.001) 0.190 0.002 (0.001, 0.004) 0.001 Attitude towards doing homework -0.720 (-1.07, -0.373 ) < 0.001 -0.019 (-0.031, -0.008) 0.001 -0.005 (-0.008, -0.003) < 0.001 0.002 (0.001, 0.004) 0.005 Living convenience -0.413 (-0.825, -0.001) 0.049 -0.014 (-0.028, -0.000) 0.043 -0.002 (-0.005, 0.001) 0.127 0.001 (-0.001, 0.003) 0.186
Table 3 Effect of four factors of quality of life on glycolipid metabolism disorder
Variable FI IR TG HDL β (95%CI) P value β (95%CI) P value β (95%CI) P value β (95%CI) P value Model 1 (four factors of QoL) Physical and mental health factor -0.222 (-0.547, 0.104) 0.181 -0.005 (-0.016, 0.006) 0.364 -0.003 (-0.005, -0.000) 0.017 0.001 (-0.000, 0.003) 0.064 Psychosocial factor -0.835 (-1.390, -0.278) 0.003 -0.021 (-0.039, -0.002) 0.026 -0.006 (-0.010, -0.002) 0.002 0.002 (-0.000, 0.005) 0.052 Living environment factor -0.821 (-1.610, -0.036) 0.040 -0.014 (-0.039, 0.012) 0.298 -0.007 (-0.012, -0.002) 0.012 0.004 (0.001, 0.008) 0.008 Quality of life satisfaction factor -0.848 (-1.610, -0.082) 0.030 -0.023 (-0.048, 0.002) 0.074 -0.006 (-0.011, -0.001) 0.031 0.001 (-0.002, 0.004) 0.507 Total score of QoL -0.440 (-0.710, -0.169) 0.002 -0.012 (-0.020, -0.003) 0.011 -0.004 (-0.006, -0.002) < 0.001 0.001 (0.000, 0.002) 0.040 Model 2 (four factors of QoL) Physical and mental health factor -0.272 (-0.588, 0.044) 0.092 -0.006 (-0.017, 0.004) 0.229 -0.002 (-0.005, -0.000) 0.039 0.001 (-0.000, 0.002) 0.122 Psychosocial factor -0.906 (-1.450, -0.367) 0.001 -0.023 (-0.041, -0.005) 0.011 -0.007 (-0.010, -0.003) 0.001 0.003 (0.001, 0.005) 0.008 Living environment factor -0.916 (-1.690, -0.143) 0.020 -0.018 (-0.044, 0.008) 0.172 -0.005 (-0.011, 0.000) 0.067 0.003 (-0.001, 0.006) 0.126 Quality of life satisfaction factor -0.965 (-1.710, -0.217) 0.012 -0.027 (-0.052, -0.002) 0.035 -0.006 (-0.011, -0.001) 0.027 0.002 (-0.001, 0.005) 0.239 Total score of QoL -0.441 (-0.705, -0.177) 0.001 -0.011 (-0.020, -0.003) 0.010 -0.004 (-0.006, -0.002) 0.001 0.001 (0.000, 0.002) 0.021
Table 4 Logistic regression analysis of dimensions of quality of life and glycolipid metabolism disorder
Variable Dyslipidemia IR > 3 Increased FBG OR (95%CI) P value OR (95%CI) P value OR (95%CI) P value Total Model 1 (domains of QoL) Self-satisfaction 0.994 (0.984, 1.003) 0.177 0.987 (0.978, 0.997) 0.009 1.009 (0.991, 1.027) 0.344 Relationship of teacher and pupil 0.991 (0.981, 1.002) 0.095 0.987 (0.977, 0.998) 0.025 1.012 (0.991, 1.032) 0.264 Activity opportunity 0.989 (0.980, 0.999) 0.031 0.988 (0.978, 0.998) 0.023 1.006 (0.988, 1.025) 0.527 Physical activity ability 0.988 (0.978, 0.998) 0.020 0.981 (0.971, 0.992) 0.001 1.013 (0.994, 1.031) 0.184 Learning ability and attitude 0.990 (0.979, 1.000) 0.057 0.989 (0.978, 1.000) 0.047 1.003 (0.984, 1.023) 0.736 Attitude towards doing homework 0.984 (0.972, 0.995) 0.004 0.986 (0.974, 0.998) 0.026 0.978 (0.959, 0.997) 0.022 Living convenience 0.997(0.984,1.011) 0.712 0.990(0.976,1.004) 0.158 0.993(0.970,1.018) 0.587 Model 2 (domains of QoL) Self-satisfaction 0.993 (0.984, 1.003) 0.183 0.986 (0.975, 0.996) 0.007 1.008 (0.989, 1.026) 0.408 Relationship of teacher and pupil 0.992 (0.981, 1.003) 0.154 0.984 (0.972, 0.996) 0.008 1.007 (0.987, 1.029) 0.480 Activity opportunity 0.988 (0.978, 0.998) 0.017 0.986 (0.975, 0.997) 0.016 1.007 (0.988, 1.026) 0.497 Physical activity ability 0.994 (0.984, 1.005) 0.268 0.985 (0.973, 0.997) 0.012 1.013 (0.994, 1.033) 0.184 Learning ability and attitude 0.990 (0.979, 1.001) 0.072 0.986 (0.974, 0.998) 0.018 1.003 (0.983, 1.023) 0.770 Attitude towards doing homework 0.982 (0.970, 0.994) 0.003 0.983 (0.971, 0.996) 0.012 0.978 (0.958, 0.997) 0.024 Living convenience 0.997 (0.983, 1.011) 0.685 0.990 (0.975, 1.005) 0.195 0.996 (0.972, 1.021) 0.765 Male Model 1 (domains of QoL) Self-satisfaction 0.996 (0.983, 1.009) 0.538 0.990 (0.977, 1.004) 0.173 1.001 (0.980, 1.023) 0.927 Relationship of teacher and pupil 0.998 (0.983, 1.012) 0.759 0.994 (0.978, 1.009) 0.414 1.003 (0.979, 1.027) 0.836 Activity opportunity 0.995 (0.981, 1.009) 0.478 0.993 (0.978, 1.008) 0.370 0.999 (0.977, 1.022) 0.942 Physical activity ability 0.993 (0.980, 1.007) 0.341 0.984 (0.970, 0.999) 0.037 1.006 (0.984, 1.028) 0.623 Learning ability and attitude 0.996 (0.981, 1.011) 0.597 0.999 (0.983, 1.016) 0.915 0.992 (0.969, 1.016) 0.503 Attitude towards doing homework 0.983 (0.968, 0.998) 0.031 0.996 (0.979, 1.013) 0.636 0.980 (0.957, 1.004) 0.102 Living convenience 1.008 (0.988, 1.027) 0.444 0.988 (0.968, 1.008) 0.229 0.982 (0.955, 1.010) 0.211 Model 2 (domains of QoL) Self-satisfaction 0.996 (0.982, 1.010) 0.570 0.991 (0.976, 1.006) 0.241 1.003 (0.981, 1.026) 0.766 Relationship of teacher and pupil 0.999 (0.984, 1.014) 0.888 0.991 (0.975, 1.008) 0.313 1.000 (0.976, 1.025) 0.982 Activity opportunity 0.993 (0.978, 1.008) 0.365 0.992 (0.976, 1.008) 0.332 1.004 (0.981, 1.027) 0.762 Physical activity ability 1.002 (0.988, 1.017) 0.745 0.991 (0.975, 1.007) 0.282 1.009 (0.986, 1.033) 0.438 Learning ability and attitude 0.996 (0.981, 1.012) 0.645 0.998 (0.980, 1.015) 0.793 0.994 (0.970, 1.018) 0.604 Attitude towards doing homework 0.980 (0.964, 0.996) 0.017 0.996 (0.977, 1.014) 0.650 0.983 (0.959, 1.008) 0.180 Living convenience 1.013 (0.992, 1.034) 0.222 0.994 (0.973, 1.016) 0.603 0.987 (0.958, 1.016) 0.363 Female Model 1 (domains of QoL) Self-satisfaction 0.991 (0.978, 1.004) 0.195 0.985 (0.972, 0.998) 0.022 1.024 (0.992, 1.056) 0.146 Relationship of teacher and pupil 0.983 (0.968, 0.999) 0.035 0.980 (0.965, 0.996) 0.012 1.029 (0.991, 1.068) 0.139 Activity opportunity 0.984 (0.971, 0.998) 0.021 0.984 (0.970, 0.998) 0.021 1.017 (0.986, 1.050) 0.292 Physical activity ability 0.982 (0.967, 0.997) 0.016 0.977 (0.962, 0.993) 0.004 1.025 (0.993, 1.058) 0.133 Learning ability and attitude 0.984 (0.969, 0.999) 0.032 0.980 (0.965, 0.995) 0.009 1.023 (0.991, 1.057) 0.164 Attitude towards doing homework 0.984 (0.968, 1.001) 0.062 0.977 (0.960, 0.994) 0.007 0.972 (0.942, 1.004) 0.084 Living convenience 0.986 (0.967, 1.006) 0.174 0.991 (0.971, 1.012) 0.387 1.018 (0.972, 1.067) 0.448 Model 2 (domains of QoL) Self-satisfaction 0.991 (0.978, 1.005) 0.230 0.981 (0.966, 0.996) 0.011 1.014 (0.981, 1.049) 0.404 Relationship of teacher and pupil 0.985 (0.969, 1.001) 0.060 0.975 (0.958, 0.992) 0.005 1.017 (0.977, 1.058) 0.420 Activity opportunity 0.984 (0.970, 0.998) 0.026 0.982 (0.967, 0.997) 0.022 1.009 (0.977, 1.043) 0.573 Physical activity ability 0.986 (0.971, 1.002) 0.097 0.976 (0.959, 0.994) 0.007 1.019 (0.983, 1.056) 0.307 Learning ability and attitude 0.984 (0.969, 1.000) 0.046 0.974 (0.958, 0.991) 0.003 1.016 (0.982, 1.051) 0.362 Attitude towards doing homework 0.983 (0.966, 1.000) 0.052 0.972 (0.954, 0.991) 0.003 0.965 (0.934, 0.997) 0.031 Living convenience 0.983 (0.963, 1.004) 0.106 0.984 (0.963, 1.007) 0.167 1.013 (0.964, 1.064) 0.613
Table 5 Logistic regression analysis of four factors of quality of life and glycolipid metabolism disorder
Variables Dyslipidemia IR Increased FBG OR (95%CI) P value OR (95%CI) P value OR (95%CI) P value Total Model 1 (four factors of QoL) Physical and mental health factor 0.992 (0.982, 1.002) 0.120 0.991 (0.980, 1.002) 0.113 1.020 (1.000, 1.041) 0.049 Psychosocial factor 0.976 (0.959, 0.994) 0.008 0.980 (0.962, 0.998) 0.034 0.995 (0.964, 1.027) 0.767 Living environment factor 0.977 (0.952, 1.001) 0.065 0.979 (0.954, 1.006) 0.121 1.077 (1.026, 1.130) 0.003 Quality of life satisfaction factor 0.992 (0.968, 1.017) 0.531 0.972 (0.948, 0.997) 0.028 1.033 (0.986, 1.082) 0.168 Total score of QoL 0.990 (0.982, 0.999) 0.025 0.988 (0.979, 0.997) 0.007 1.009 (0.993, 1.025) 0.267 Model 2 (four factors of QoL) Physical and mental health factor 0.994 (0.983, 1.005) 0.296 0.988 (0.976, 1.000) 0.047 1.015 (0.994, 1.036) 0.154 Psychosocial factor 0.973 (0.953, 0.993) 0.010 0.973 (0.953, 0.993) 0.010 0.992 (0.960, 1.025) 0.620 Living environment factor 0.988 (0.962, 1.015) 0.387 0.971 (0.942, 1.000) 0.053 1.060 (1.008, 1.115) 0.024 Quality of life satisfaction factor 0.992 (0.966, 1.017) 0.520 0.961 (0.934, 0.988) 0.005 1.024 (0.977, 1.074) 0.320 Total score of QoL 0.991 (0.982, 1.000) 0.043 0.985 (0.976, 0.995) 0.004 1.009 (0.992, 1.026) 0.317 Male Model 1 (four factors of QoL) Physical and mental health factor 0.999 (0.985, 1.014) 0.899 0.999 (0.983, 1.015) 0.913 1.016 (0.992, 1.042) 0.196 Psychosocial factor 0.981 (0.957, 1.005) 0.124 0.998 (0.972, 1.025) 0.889 0.982 (0.945, 1.021) 0.355 Living environment factor 1.001 (0.966, 1.038) 0.935 0.987 (0.950, 1.026) 0.514 1.060 (0.998, 1.125) 0.057 Quality of life satisfaction factor 1.002 (0.968, 1.037) 0.916 0.986 (0.950, 1.023) 0.459 1.018 (0.962, 1.077) 0.537 Total score of QoL 0.995 (0.983, 1.008) 0.470 0.995 (0.982, 1.009) 0.482 1.003 (0.983, 1.023) 0.799 Model 2 (four factors of QoL) Physical and mental health factor 1.002 (0.986, 1.017) 0.824 0.999 (0.982, 1.016) 0.895 1.013 (0.988, 1.039) 0.301 Psychosocial factor 0.994 (0.965, 1.024) 0.686 0.994 (0.965, 1.024) 0.686 0.983 (0.945, 1.024) 0.414 Living environment factor 1.021 (0.982, 1.062) 0.299 0.989 (0.947, 1.033) 0.633 1.047 (0.983, 1.114) 0.154 Quality of life satisfaction factor 1.001 (0.964, 1.039) 0.969 0.982 (0.943, 1.022) 0.374 1.016 (0.959, 1.077) 0.580 Total score of QoL 0.997 (0.984, 1.010) 0.645 0.996 (0.982, 1.011) 0.601 1.005 (0.984, 1.026) 0.631 Female Model 1 (four factors of QoL) Physical and mental health factor 0.984 (0.970, 0.999) 0.037 0.983 (0.968, 0.998) 0.026 1.025 (0.990, 1.061) 0.160 Psychosocial factor 0.971 (0.946, 0.996) 0.024 0.962 (0.936, 0.988) 0.004 1.020 (0.965, 1.079) 0.477 Living environment factor 0.952 (0.919, 0.987) 0.008 0.970 (0.935, 1.006) 0.105 1.102 (1.016, 1.195) 0.019 Quality of life satisfaction factor 0.983 (0.950, 1.017) 0.329 0.958 (0.925, 0.992) 0.016 1.056 (0.976, 1.143) 0.173 Total score of QoL 0.985 (0.973, 0.997) 0.014 0.980 (0.968, 0.993) 0.002 1.020 (0.992, 1.049) 0.156 Model 2 (four factors of QoL) Physical and mental health factor 0.987 (0.971, 1.003) 0.103 0.976 (0.960, 0.993) 0.007 1.011 (0.974, 1.049) 0.565 Psychosocial factor 0.956 (0.929, 0.984) 0.003 0.956 (0.929, 0.984) 0.003 1.006 (0.950, 1.065) 0.846 Living environment factor 0.962 (0.925, 1.000) 0.048 0.951 (0.912, 0.992) 0.019 1.072 (0.982, 1.171) 0.120 Quality of life satisfaction factor 0.984 (0.948, 1.021) 0.393 0.941 (0.905, 0.978) 0.002 1.025 (0.942, 1.115) 0.568 Total score of QoL 0.985 (0.972, 0.998) 0.024 0.975 (0.961, 0.989) 0.001 1.012 (0.982, 1.043) 0.445