Zhou W, Ye SD, Wang W. Elevated retinol binding protein 4 levels are associated with atherosclerosis in diabetic rats via JAK2/STAT3 signaling pathway. World J Diabetes 2021; 12(4): 466-479 [PMID: 33889291 DOI: 10.4239/wjd.v12.i4.466]
Corresponding Author of This Article
Wei Wang, PhD, Chief Doctor, Department of Endocrinology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, No. 17 Lujiang Road, Hefei 230001, Anhui Province, China. hfww2001@ustc.edu.cn
Research Domain of This Article
Cardiac & Cardiovascular Systems
Article-Type of This Article
Basic Study
Open-Access Policy of This Article
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Table 4 Correlation between serum retinol binding protein 4 and the other indicators in type 2 diabetes groups (n = 50)
Indicator
r
P value
Weight (kg)
0.121
0.401
TG (mmol/L)
0.622
< 0.001
LDL-c (mmol/L)
0.395
0.005
HDL-c (mmol/L)
-0.566
< 0.001
TC (mmol/L)
0.586
< 0.001
AI
0.716
< 0.001
FPG (mmol/L)
0.111
0.444
FINS (mU/L)
0.556
< 0.001
HOMA-IR
0.541
< 0.001
HbA1C (%)
0.284
0.045
JAK2
0.239
0.094
p-JAK2
0.433
0.002
STAT3
-0.040
0.781
p-STAT3
0.539
< 0.001
Cyclin D1
0.476
< 0.001
Bcl-2
0.325
0.021
Table 5 Multivariable logistic regression in type 2 diabetes groups (n = 50)
Variable
β value
SE
χ2
OR
95%CI
P value
RBP4
0.951
0.338
7.933
2.589
1.335-5.019
0.005
LDL-c
5.211
2.421
4.631
18.253
1.592-39.597
0.031
p-JAK2
2.040
0.866
5.554
7.693
1.410-41.979
0.018
p-STAT3
2.734
1.187
5.305
15.402
1.503-57.794
0.021
Constant
-21.007
7.916
7.041
0.000
0.008
Citation: Zhou W, Ye SD, Wang W. Elevated retinol binding protein 4 levels are associated with atherosclerosis in diabetic rats via JAK2/STAT3 signaling pathway. World J Diabetes 2021; 12(4): 466-479