Influence of 10-(6-plastoquinonyl) decyltriphenylphosphonium on free-radical homeostasis in the heart and blood serum of rats with streptozotocin-induced hyperglycemia

Table 1 Glucose concentration in rats’ blood

	Glucose concentration in rats’ blood, mmol/L
	The 9th d after STZ administration	The 11th d after STZ administration
Control group	5.09 ± 0.081	5.41 ± 0.088
Animals with experimental hyperglycemia induced by streptozotocin	10.01 ± 0.166a	14.6 ± 0.241a
SkQ1 is administered to animals with pathology	6.04 ± 0.099b	5.87 ± 0.096b
SkQ1 is administered to animals at control group	5.1 ± 0.083	5.30 ± 0.086

^aP ≤ 0.0167 compared with control;

^bP ≤ 0.0167 compared with pathology. SkQ1: 10-(6-plastoquinonyl) decyltriphenylphosphonium; STZ: Streptozotocin.

Table 2 Parameters reflecting the level of free radical processes and general antioxidant system activity

Parameters		Experiment conditions
		Control group	Animals with experimental hyperglycemia induced by streptozotocin	SkQ1 is administered to animals with pathology	SkQ1 is administered to animals at control group
Biochemicoluminescence measurements
Light sum, mV × c	Heart	485.01 ± 7.912	1062.76 ± 17.124a	818.76 ± 13.611b	478.33 ± 7.971
	Blood serum	307.70 ± 5.141	654.14 ± 10.114a	410.53 ± 6.713b	302.33 ± 5.012
Maximum flash intensity, mV	Heart	51.53 ± 0.851	126.93 ± 1.987a	83.10 ± 1.374b	47.33 ± 0.779
	Blood serum	25.20 ± 0.412	52.23 ± 0.864a	33.67 ± 0.559b	22.15 ± 0.362
Angle tangent of slope of kinetic curve of biochemicoluminescence pathway	Heart	7.10 ± 0.101	14.94 ± 0.241a	10.10 ± 0.165b	7.05 ± 0.112
	Blood serum	13.33 ± 0.223	30.43 ± 0.498a	21.71 ± 0.359b	12.93 ± 0.183
Content of conjugated dienes, μmol/mL	Heart	17.70 ± 0.281	41.90 ± 0.687a	29.76 ± 0.492b	17.22 ± 0.267
	Blood serum	7.55 ± 0.122	24.83 ± 0.401a	15.00 ± 0.247b	7.33 ± 0.113
Level of carbonyl compounds, nmol/L/mg of protein	Heart	0.072 ± 0.001	0.199 ± 0.003a	0.136 ± 0.002b	0.070 ± 0.001
	Blood serum	0.021 ± 0.0003	0.154 ± 0.002a	0.076 ± 0.001b	0.019 ± 0.0003
Citrate content, nmol/L	Heart	0.201 ± 0.003	0.43 ± 0.007a	0.28 ± 0.004b	0.204 ± 0.003
	Blood serum	0.57 ± 0.0097	1.45 ± 0.021	1.07 ± 0.016b	0.59 ± 0.0093

^aP ≤ 0.0167 compared with control;

^bP ≤ 0.0167 compared with pathology. SkQ1: 10-(6-plastoquinonyl) decyltriphenylphosphonium.