Type 1 diabetes in a Nigerian family - occurrence in three out of four siblings: A case report

Table 1 Laboratory parameters of the siblings at diagnosis

	Sibling 1	Sibling 2	Sibling 3
Age of diagnosis, yr	15	11	9
BG at presentation, mg/dL BMI, kg/m2	403 23	448 28.4	337 22.4
Mode of presentation of diagnosis	DKA	DKA	DKA
HbA1C, %	10.7	11.0	10.7
Urinalysis
Glucose	4+	4+	3+
Ketone	3+	3+	2+
Serum C-peptide levels, pmol/L	< 33.0 (364-1655)	Undetectable	Low
Anti-GAD antibodies, IU/mL (Normal range: 0.0-10.0)	1561.0	1208.8	1054.2
Anti-IA-2 Ab	Increased	Increased	Increased
TPO Ab, U/mL	Normal	Normal	Normal

BG: Blood glucose; BMI: Body mass index; DKA: Diabetic ketoacidosis; HbA1C: Glycated hemoglobin; GAD: Glutamic acid decarboxylase; IA-2 Ab: Insulinoma-associated protein-2 antibody; TPO Ab: Thyroid peroxidase antibody.