Cardiac autonomic neuropathy in patients with diabetes mellitus

Figure 1 Summary of the mechanisms that relate hyperglycaemia to microvascular complications in patients with diabetes. PKC: Protein kinase C; AGE: Advanced glycation end-products; PARP: Poly ADP-ribose polymerase; GAPDH: Glyceraldehyde-3 phosphate dehydrogenase; GSH: Glutathione; NADH: Nicotinamide adenine dinucleotide; TGF-β: Transforming growth factor; VEGF: Vascular endothelial growth factor; PAI-1: Plasminogen activator inhibitor-1; eNOS: Endothelial nitric oxide synthase; IL-1: Interleukin 1; TNF-α: Tumour necrosis factor-α; VCAM-1: Vascular cell adhesion molecule 1.

Figure 2 Natural progression of CAN and correlation with clinical signs and symptoms. CAN: Cardiac autonomic neuropathy; LV: Left ventricle.

Figure 3 Current recommendations on screening for cardiac autonomic neuropathy. CAN: Cardiac autonomic neuropathy; DM: Diabetes mellitus.