Gastrointestinal neuroregulation in diabetic gastroenteropathy: Integrating molecular mechanisms and diagnostic approaches

doi:10.4239/wjd.115749

Advanced Search

BPG is committed to discovery and dissemination of knowledge

Home / Archive / Volume 17, Issue 9

This Article

(1)

(0)

(1)

(14)

Peer-Review Report of This Article

CrossCheck and Google Search of This Article

Academic Rules and Norms of This Article

Citation of this article

Corresponding Author of This Article

Research Domain of This Article

Article-Type of This Article

Open-Access Policy of This Article

Times Cited Counts in Google of This Article

Journal Information of This Article

Publication Name

World Journal of Diabetes

ISSN

1948-9358

Publisher of This Article

Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Review

Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Diabetes. Sep 15, 2026; 17(9): 115749
Published online Sep 15, 2026. doi: 10.4239/wjd.115749

Open in New Tab Full Size Figure Download Figure

Figure 1 Mechanisms of cytokine and neuroimmune interactions and gastrointestinal brain axis among sympathetic, vagus, and enteric nerves in diabetic gastrointestinal lesions. VIP: Vasoactive intestinal peptide; GLP-1: Glucagon-like peptide-1; 5-HT: 5-hydroxytryptamine; Ach: Acetylcholine; NO: Nitric oxide; SCFA: Short chain fatty acids; GABA: Gamma-aminobutyric acid; IL-6: Interleukin-6; Trpa 1: Transient receptor potential anchor protein 1; nNOS: Neuronal nitric oxide synthase; NE: Norepinephrine.

Open in New Tab Full Size Figure Download Figure

Figure 2 Microscopic mechanistic diagram of cytokines in diabetic gastroenteropathy. 5-HT: 5-hydroxytryptamine; NO: Nitric oxide; VIP: Vasoactive intestinal peptide; TRPA1: Transient receptor potential anchor protein 1; NOX: NADPH oxidase; AGEs: Advanced glycation end products; GABA: Gamma-aminobutyric acid; SCFA: Short-chain fatty acids; IECs: Intestinal epithelial cells; FFAR: Free fatty acid receptor; MCT: Monocarboxylate transporter; GMGBA: Gut microbiota-gut-brain axis; Ach: Acetylcholine; nNOS: Neuronal nitric oxide synthase; POMC: Pro-opiomelanocortin; sGC: Soluble guanylate cyclase; ICC: Interstitial cells of Cajal; GLP-1: Glucagon-like peptide-1; GPCR: G protein-coupled receptor; VPAC1: Vasoactive intestinal peptide receptor 1; IL-22: Interleukin-22; ASIC3: Acid-sensing ion channel 3; GFAP: Glial fibrillary acidic protein; NPY/AgRP: Neuropeptide Y/agouti-related protein; CCK: Cholecystokinin; GAS: Gastrin; Gsα-AC-cAMP: G protein stimulatory α subunit-adenylyl cyclase-cyclic adenosine monophosphate; HDAC: Histone deacetylase.

Citation: Yin RY, Liu ZJ, Yao YQ, Miao RY, Guan HF, Zhang YX, Fang XY, Zhang YJ, Tian JX. Gastrointestinal neuroregulation in diabetic gastroenteropathy: Integrating molecular mechanisms and diagnostic approaches. World J Diabetes 2026; 17(9): 115749
URL: https://www.wjgnet.com/1948-9358/full/v17/i9/115749.htm
DOI: https://dx.doi.org/10.4239/wjd.115749

Yin RY, Liu ZJ, Yao YQ, Miao RY, Guan HF, Zhang YX, Fang XY, Zhang YJ, Tian JX. Gastrointestinal neuroregulation in diabetic gastroenteropathy: Integrating molecular mechanisms and diagnostic approaches. World J Diabetes 2026; 17(9): 115749 [DOI: 10.4239/wjd.115749]

All content on this site: Copyright © 1993-2026 Baishideng Publishing Group Inc, its licensors, and contributors. All rights are reserved, including those for text and data mining, AI training, and similar technologies. For all open access content, the relevant licensing terms apply.