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World J Diabetes. Sep 15, 2026; 17(9): 115749
Published online Sep 15, 2026. doi: 10.4239/wjd.115749
Published online Sep 15, 2026. doi: 10.4239/wjd.115749
Gastrointestinal neuroregulation in diabetic gastroenteropathy: Integrating molecular mechanisms and diagnostic approaches
Rui-Yang Yin, Yi-Qi Yao, Run-Yu Miao, Yu-Xin Zhang, Yan-Jiao Zhang, Jia-Xing Tian, Institute of Metabolic Diseases, Guang’anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, China
Zi-Jian Liu, Beijing University of Chinese Medicine, Beijing 100029, China
Hui-Fang Guan, Graduate College, Changchun University of Chinese Medicine, Changchun 130117, Jilin Province, China
Xin-Yi Fang, Graduate College, Beijing University of Chinese Medicine, Beijing 100029, China
Jia-Xing Tian, Department of Endocrinology, The Affiliated Hospital of Changchun University of Chinese Medicine, Changchun 130022, Jilin Province, China
Co-first authors: Rui-Yang Yin and Zi-Jian Liu.
Author contributions: Yin RY, Liu ZJ, Yao YQ, Miao RY, Guan HF, Zhang YX, Fang XY, Zhang YJ, and Tian JX conceptualized the study and designed the research framework; Yin RY and Liu ZJ collected and organized the literature data and they contributed equally to this work as co-first authors; Yin RY, Liu ZJ, and Yao YQ analyzed and interpreted the research findings; Miao RY, Guan HF, and Zhang YX contributed to the discussion of neural regulation mechanisms and diagnostic approaches; Fang XY and Zhang YJ provided technical support for data sorting and figure construction; Tian JX supervised the entire research process, revised the manuscript critically for important intellectual content, and approved the final version to be published. All authors read and agreed to the published version of the manuscript.
Supported by High Level Chinese Medical Hospital Promotion Project, No. HLCMHPP20230CZ40907; CACMS Outstanding Young Scientific and Technological Talents Program, No. ZZ13-YQ-026; GAMIMD Special Fund, No. 2022 LYJSZX12; and CACM-PDP Dose-effect Relationship Research Project, No. 202428-002.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Corresponding author: Jia-Xing Tian, Department of Endocrinology, The Affiliated Hospital of Changchun University of Chinese Medicine, No. 1478 Gongnong Road, Chaoyang District, Changchun 130022, Jilin Province, China. tina_yai@126.com
Received: October 24, 2025
Revised: February 28, 2026
Accepted: May 25, 2026
Published online: September 15, 2026
Processing time: 311 Days and 18.2 Hours
Revised: February 28, 2026
Accepted: May 25, 2026
Published online: September 15, 2026
Processing time: 311 Days and 18.2 Hours
Core Tip
Core Tip: Diabetic gastroenteropathy (DGP) arises from multi-level neural regulatory dysfunction; this study systematically clarifies the synergic dysregulation of the sympathetic-vagus-enteric nervous system, constructs a DGP neural regulatory network, and integrates gastrointestinal motility detection technologies to provide novel insights for DGP’s pathophy