Synergistic mechanism of adipose-derived stem cells in healing diabetic foot ulcers

doi:10.4239/wjd.v17.i5.116210

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May 15, 2026 (publication date) through May 14, 2026

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World Journal of Diabetes

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1948-9358

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Diabetes. May 15, 2026; 17(5): 116210
Published online May 15, 2026. doi: 10.4239/wjd.v17.i5.116210

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Figure 1 A dosage of 5 × 10⁵ adipose-derived stem cells was identified as optimal for diabetic wound repair in mice. The treatment promoted healing through a multimodal action: Stimulating angiogenesis via the PI3K/AKT/mTOR/HIF-1α/VEGF signaling pathway, enhancing collagen I and III deposition by suppressing Notch1 expression, and facilitating immune modulation by shifting macrophages from the M1 to the M2 phenotype. ADSC: Adipose-derived stem cell. Created with biogdp.com (Supplementary material).

Citation: Wan XX, Yan WT, He WH, Xiong K. Synergistic mechanism of adipose-derived stem cells in healing diabetic foot ulcers. World J Diabetes 2026; 17(5): 116210
URL: https://www.wjgnet.com/1948-9358/full/v17/i5/116210.htm
DOI: https://dx.doi.org/10.4239/wjd.v17.i5.116210

Wan XX, Yan WT, He WH, Xiong K. Synergistic mechanism of adipose-derived stem cells in healing diabetic foot ulcers. World J Diabetes 2026; 17(5): 116210 [DOI: 10.4239/wjd.v17.i5.116210]

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