Exosomal miR-375-3p as a mediator of pancreas-liver crosstalk in impaired hepatic glycogenesis

Figure 1 Exosome-mediated regulation of hepatocyte glycogen metabolism in type 2 diabetes mellitus. Exosomes secreted from pancreatic β-cells deliver miR-375-3p to hepatocytes, where it targets Rbpj and subsequently modulates the AKT/GSK signaling pathway to regulate glycogenesis. Solid arrows indicate experimentally confirmed mechanisms, while dashed arrows indicate potential extendable pathways, including possible feedback mechanisms to pancreatic β-cells and links to systemic insulin resistance.