Copyright
©The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Diabetes. Jan 15, 2026; 17(1): 114251
Published online Jan 15, 2026. doi: 10.4239/wjd.v17.i1.114251
Published online Jan 15, 2026. doi: 10.4239/wjd.v17.i1.114251
Exosomal miR-375-3p as a mediator of pancreas-liver crosstalk in impaired hepatic glycogenesis
Tian-Han Xu, Dong-Mei Wang, Department of Gastrointestinal Surgery, Affiliated Changzhou No. 2 People’s Hospital of Nanjing Medical University, The Third Affiliated Hospital of Nanjing Medical University, Changzhou Medical Center, Nanjing Medical University, Changzhou 213000, Jiangsu Province, China
Author contributions: Xu TH jointly conceived the idea of this letter, collected the relevant data and drafted the manuscript; Wang DM provided critical revisions and overall supervision; both authors approved the final version of the letter.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Dong-mei Wang, PhD, Professor, Department of Gastrointestinal Surgery, Affiliated Changzhou No. 2 People’s Hospital of Nanjing Medical University, The Third Affiliated Hospital of Nanjing Medical University, Changzhou Medical Center, Nanjing Medical University, No. 68 Gehu Middle Road, Changzhou 213000, Jiangsu Province, China. fautywang@163.com
Received: September 15, 2025
Revised: October 24, 2025
Accepted: November 19, 2025
Published online: January 15, 2026
Processing time: 121 Days and 16.6 Hours
Revised: October 24, 2025
Accepted: November 19, 2025
Published online: January 15, 2026
Processing time: 121 Days and 16.6 Hours
Core Tip
Core Tip: Xu et al revealed that pancreatic β-cell-derived exosomal miR-375-3p inhibits Rbpj expression in hepatocytes, leading to the suppression of the AKT/GSK signaling pathway and impaired hepatic glycogenesis. Their study identified a novel exosome-mediated pancreas-liver communication axis in the progression of diabetes, underscoring the promising role of exosomal microRNAs as both diagnostic biomarkers and therapeutic targets.