Zebrafish as a preclinical model for diabetes mellitus and its complications: From monogenic to gestational diabetes and beyond

doi:10.4239/wjd.v16.i5.100574

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May 15, 2025 (publication date) through Apr 25, 2025

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World Journal of Diabetes

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1948-9358

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Diabetes. May 15, 2025; 16(5): 100574
Published online May 15, 2025. doi: 10.4239/wjd.v16.i5.100574

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Figure 1 Zebrafish as a model in diabetes research. A: Zebrafish as a model in diabetes due to genetic similarity with humans; B: Applications of zebrafish in modeling various types of diabetes; C: Diagram showing the resected zebrafish pancreas. T1DM: Type 1 diabetes mellitus; T2DM: Type 2 diabetes mellitus; GDM: Gestational diabetes mellitus; GCKD: Glomerular cystic kidney disease.

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Figure 2 Drug modification approaches for inducing β-cell regeneration. DMFO: Difluoromethylornithine; STZ: Streptozotocin.

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Figure 3 Small molecules promoting β-cell regeneration. Arx: Aristaless related homeobox; 12-LOX: 12-lipoxygenase.

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Figure 4 Construction methods for zebrafish models of type 2 diabetes mellitus models. T2DM: Type 2 diabetes mellitus.

Citation: Huang J, Chen YL. Zebrafish as a preclinical model for diabetes mellitus and its complications: From monogenic to gestational diabetes and beyond. World J Diabetes 2025; 16(5): 100574
URL: https://www.wjgnet.com/1948-9358/full/v16/i5/100574.htm
DOI: https://dx.doi.org/10.4239/wjd.v16.i5.100574