Zebrafish as a preclinical model for diabetes mellitus and its complications: From monogenic to gestational diabetes and beyond

doi:10.4239/wjd.v16.i5.100574

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World Journal of Diabetes

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World J Diabetes. May 15, 2025; 16(5): 100574
Published online May 15, 2025. doi: 10.4239/wjd.v16.i5.100574

Zebrafish as a preclinical model for diabetes mellitus and its complications: From monogenic to gestational diabetes and beyond

Yin-Ling Chen, Jie Huang

Jie Huang, Yin-Ling Chen, School of Medicine, Hangzhou City University, Hangzhou 310000, Zhejiang Province, China

Author contributions: Huang J analyzed the literature and wrote the manuscript; Chen YL designed the study; both authors contributed significantly to the literature analysis and reviewed and approved the final manuscript.

Supported by Natural Science Foundation of Zhejiang Province, China, No. LQ24H070007.

Conflict-of-interest statement: Both authors report no relevant conflicts of interest for this article.

Corresponding author: Yin-Ling Chen, PhD, Lecturer, School of Medicine, Hangzhou City University, No. 51 Huzhou Road, Hangzhou 310000, Zhejiang Province, China. chenyinling6666@163.com

Received: August 21, 2024
Revised: December 13, 2024
Accepted: March 19, 2025
Published online: May 15, 2025
Processing time: 247 Days and 22.4 Hours

Core Tip

Core Tip: Notably, zebrafish has been established as a model organism in diabetes research, providing unique insights into pathological progression, therapeutic efficacy evaluation, and complication pathogenesis owing to its accelerated developmental cycles, optical clarity, and genetic tractability. Particularly, its experimental versatility has enabled successful recapitulation of type 1 and type 2 diabetes pathogenesis while providing platforms for systematic investigation of monogenic variants and pregnancy-associated metabolic dysregulation. Collectively, these scientific advancements represent transformative potential for advancing mechanistic comprehension and developing targeted interventions against diabetes mellitus and its secondary complications.