Methylation status of leptin gene promoter in relatively lean Chinese adults with prediabetes and type 2 diabetes mellitus

Figure 1 Leptin promoter methylation rates decrease significantly across glycemic states in lean Chinese adults (body mass index < 24 kg/m²). Methylation levels in type 2 diabetes mellitus were 315% lower than normal glucose tolerance (NGT) (59.2%, P < 0.001) and lower than impaired glucose tolerance (IGT) (48%, P < 0.001). Error bars: 95%CI. Data derived from methylation-specific PCR analysis of peripheral leukocytes (n = 392). ^cP < 0.001: Compared to NGT and IGT. IGT: Impaired glucose tolerance; IGR: Impaired glucose regulation; NGT: Normal glucose tolerance; T2DM: Type 2 diabetes mellitus.