Glucose metabolism profile recorded by flash glucose monitoring system in patients with hypopituitarism during prednisone replacement

Figure 1 Glucose-target-rate profile. A: Comparison of patient group to normal controls (NCs); B: Comparison of prednisone (Pred) > 5 mg/d group and Pred ≤ 5 mg/d group to NCs. Data are denoted as means. PG: Patient group; NCs: Normal controls; Pred: Prednisone; PT: Percentile time; TIR: Time in range; TOR: Time out of range.

Figure 2 Glucose variability profile. A: Comparison of patient group to normal controls (NCs); B: Comparison of prednisone (Pred) > 5 mg/d group and Pred ≤ 5 mg/d group to NCs. Data are denoted as mean ± SE. ^aP < 0.05. PG: Patient group; NCs: Normal controls; Pred: Prednisone; GV: Glucose variability; MG: Mean glucose; CV: Coefficient of variance; MODD: Mean of daily difference; IQR: Interquartile range.

Figure 3 Comparison of glucose level and area under the curve between patient group and normal controls. A: Glucose level during whole day; B: Glucose level at 0-3 am period; C: Glucose level at 3-8 am period; D: Glucose level after breakfast; E: Glucose level after lunch; F: Glucose level after dinner; G: Area under the curve (AUC) at 0-3 am period and 3-8 am period; H: AUC at postprandial periods. Data are denoted as mean ± SE. ^aP < 0.05. AUC: Area under the curve; PG: Patient group; NCs: Normal controls; BF: Breakfast.

Figure 4 Hypoglycemia occurrence. A: Comparison of patient group to normal controls (NCs); B: Comparison of prednisone (Pred) > 5 mg/d group and Pred ≤ 5 mg/d group to NCs. Data are showed as median, interquartile range, and interdecile range. ^aP < 0.05. PG: Patient group; NCs: Normal controls; Pred: Prednisone; IQR: Interquartile range.

Figure 5 Glucose level and area under the curve during the day, at 0-3 am, period and at 3-8 am period. Comparison of prednisone (Pred) > 5mg/d group to normal controls (NCs): A1, during the day; A2, at 0-3am; A3, at 3-8am; A4, AUC. Comparison of prednisone (Pred) ≤ 5mg/d group to normal controls (NCs): B1, during the day; B2, at 0-3am; B3, at 3-8am; B4, AUC. Data are denoted as mean ± SE. ^aP < 0.05. AUC: Area under the curve; NCs: Normal controls; Pred: Prednisone.

Figure 6 Glucose level and area under the curve at postprandial phase. Comparison of prednisone (Pred)>5mg/d group to normal controls (NCs): A1, afetr BF; A2, after lunch; A3, after dinner; A4, AUC. Comparison of prednisone (Pred) ≤ 5mg/d group to normal controls (NCs): B1, after BF; B2, after lunch; B3, after dinner; B4, AUC. Data are denoted as mean ± SE. ^aP < 0.05. AUC: Area under the curve; NCs: Normal controls; Pred: Prednisone; BF: Breakfast.