Gautam A, Gupta S, Mehndiratta M, Sharma M, Singh K, Kalra OP, Agarwal S, Gambhir JK. Association of NFKB1 gene polymorphism (rs28362491) with levels of inflammatory biomarkers and susceptibility to diabetic nephropathy in Asian Indians. World J Diabetes 2017; 8(2): 66-73 [PMID: 28265344 DOI: 10.4239/wjd.v8.i2.66]
Corresponding Author of This Article
Jasvinder K Gambhir, PhD, Professor, Molecular Diagnostic Laboratory, Department of Biochemistry, University College of Medical Sciences (University of Delhi) and G.T.B. Hospital, Dilshad Garden, Delhi 110095, India. jassigambhir@yahoo.co.in
Research Domain of This Article
Biochemistry & Molecular Biology
Article-Type of This Article
Case Control Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Share the Article
Gautam A, Gupta S, Mehndiratta M, Sharma M, Singh K, Kalra OP, Agarwal S, Gambhir JK. Association of NFKB1 gene polymorphism (rs28362491) with levels of inflammatory biomarkers and susceptibility to diabetic nephropathy in Asian Indians. World J Diabetes 2017; 8(2): 66-73 [PMID: 28265344 DOI: 10.4239/wjd.v8.i2.66]
World J Diabetes. Feb 15, 2017; 8(2): 66-73 Published online Feb 15, 2017. doi: 10.4239/wjd.v8.i2.66
Association of NFKB1 gene polymorphism (rs28362491) with levels of inflammatory biomarkers and susceptibility to diabetic nephropathy in Asian Indians
Amar Gautam, Stuti Gupta, Mohit Mehndiratta, Mohini Sharma, Kalpana Singh, Om P Kalra, Sunil Agarwal, Jasvinder K Gambhir
Amar Gautam, Om P Kalra, Sunil Agarwal, Department of Medicine, University College of Medical Sciences (University of Delhi) and G.T.B. Hospital, Delhi 110095, India
Stuti Gupta, Mohit Mehndiratta, Mohini Sharma, Kalpana Singh, Jasvinder K Gambhir, Molecular Diagnostic Laboratory, Department of Biochemistry, University College of Medical Sciences (University of Delhi) and G.T.B. Hospital, Delhi 110095, India
Author contributions: Gautam A and Gupta S contributed equally to this article; Gautam A, Gupta S, Sharma M and Singh K performed sample collection, majority of experiments, analyzed data and wrote manuscript; Mehndiratta M, Kalra OP, Agarwal S and Gambhir JK contributed to conceptual and study design, data analysis and interpretation, as well as manuscript writing.
Institutional review board statement: The protocol of the present study was reviewed and approved by Institutional Ethics Committee for Human Research, Delhi University, and UCMS and GTB Hospital, Delhi.
Informed consent statement: Informed consent was obtained from the all recruited subjects. They were briefed on the purpose of the study and its implication prior to donating peripheral blood.
Conflict-of-interest statement: No conflict of interest exists for this study.
Data sharing statement: No data sharing as this manuscript and the data were not published elsewhere.
Correspondence to: Jasvinder K Gambhir, PhD, Professor, Molecular Diagnostic Laboratory, Department of Biochemistry, University College of Medical Sciences (University of Delhi) and G.T.B. Hospital, Dilshad Garden, Delhi 110095, India. jassigambhir@yahoo.co.in
Telephone: +91-98-11641277
Received: September 12, 2016 Peer-review started: September 19, 2016 First decision: October 21, 2016 Revised: December 6, 2016 Accepted: December 27, 2016 Article in press: December 28, 2016 Published online: February 15, 2017 Processing time: 155 Days and 17 Hours
Core Tip
Core tip: Type 2 diabetes mellitus (T2DM) is considered as long standing inflammatory disease. Diabetic nephropathy (DN) is the most common micro-vascular complication of T2DM. Pro-inflammatory cytokines like Monocyte chemoattractant protein-1 (MCP-1) and tumor necrosis factor-alpha (TNF-α) plays a crucial role in the pathogenesis of DN. Therefore we investigated -94 ins/del ATTG polymorphism in NFKB1 gene and its association with the risk of DN in Asian Indians. -94 ins/del ATTG single nucleotide polymorphism was found to increase the urinary MCP-1 and plasma TNF-α levels. Our findings open a new area of research to explore that -94 ins/del ATTG may be considered as genetic markers for early detection of diabetic patients who are at greater risk of development of nephropathy.
