©The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Diabetes. Jan 15, 2017; 8(1): 11-17
Published online Jan 15, 2017. doi: 10.4239/wjd.v8.i1.11
Published online Jan 15, 2017. doi: 10.4239/wjd.v8.i1.11
Serum levels of undercarboxylated osteocalcin are related to cardiovascular risk factors in patients with type 2 diabetes mellitus and healthy subjects
Sergio Sanchez-Enriquez, Isabel Thalia Ballesteros-Gonzalez, Edgar Alfonso Rivera-Leon, Juan Luis Alcala-Zermeno, Iris Monserrat Llamas-Covarrubias, Biochemistry Laboratory, Molecular Biology and Genomics Department, University Center of Health Sciences, University of Guadalajara, CP 44340 Guadalajara, Jalisco, Mexico
Sergio Sanchez-Enriquez, Edgar Alfonso Rivera-Leon, Blanca Estela Bastidas-Ramirez, Jorge David Rivas-Carrillo, Juan Luis Alcala-Zermeno, Abraham Zepeda-Moreno, Academic Group UDG-CA-533 Multidisciplinary Study of Chronic and Degenerative Diseases, Molecular Biology and Genomics Department, University Center of Health Sciences, University of Guadalajara, CP 44340 Guadalajara, Jalisco, Mexico
José Rafael Villafán-Bernal, Departamento de Jóvenes, Investigadores y Cátedras del Consejo Nacional de Ciencia y Tecnología (CONACYT), CP 03940 Benito Juárez, México
José Rafael Villafán-Bernal, Departamento de Cirugía, Centro Universitario de Ciencias de la Salud, Universidad Autónoma de Aguascalientes, CP 20131 Aguascalientes, Ags, México
Sara Pascoe-Gonzalez, Physiology Department, University Center of Health Sciences, University of Guadalajara, CP 44340 Guadalajara, Jalisco, Mexico
Blanca Estela Bastidas-Ramirez, Institute of Degenerative Chronic Diseases, Molecular Biology and Genomics Department, University Center of Health Sciences, University of Guadalajara, CP 44340 Guadalajara, Jalisco, Mexico
Juan Armendariz-Borunda, Head of Molecular Biology and Genomics Department, University Center of Health Sciences, University of Guadalajara, CP 44340 Guadalajara, Jalisco, Mexico
Abraham Zepeda-Moreno, Institute of Cancer Research in Child and Adolescent, University Center of Health Sciences, University of Guadalajara, CP 44340 Guadalajara, Jalisco, Mexico
Author contributions: Sanchez-Enriquez S and Zepeda-Moreno A designed the research; Ballesteros-Gonzalez IT, Villafán-Bernal JR and Pascoe-Gonzalez S performed the research; Rivera-Leon EA and Llamas-Covarrubias IM contributed new reagents/analytic tools; Bastidas-Ramirez BE and Rivas-Carrillo JD analyzed the data; Alcala-Zermeno JL and Armendariz-Borunda J wrote the paper.
Institutional review board statement: The study was reviewed and approved by the Universidad de Guadalajara, Centro Universitario de Ciencias de la Salud Institutional Review Board.
Informed consent statement: All study participants, or their legal guardian,provided informed verbal consent prior to study enrolment.
Conflict-of-interest statement: There are no conflicts of interest to report.
Data sharing statement: Technical appendix, statistical code, and dataset will be available from Sergio Sanchez-Enriquez at Dryad repository, who will provide a permanent, citable and open-access home for the dataset.
Correspondence to: Sergio Sanchez-Enriquez, MD, MSc, PhD, Biochemistry Laboratory, Molecular Biology and Genomics Department, University Center of Health Sciences, University of Guadalajara, Sierra Mojada No. 950, Colonia Independencia, CP 44340 Guadalajara, Jalisco, Mexico. serlucis@hotmail.com
Telephone: +52-33-10585200-33644 Fax: +52-33-10585200-33644
Received: September 11, 2016
Peer-review started: September 12, 2016
First decision: September 30, 2016
Revised: October 21, 2016
Accepted: November 16, 2016
Article in press: November 17, 2016
Published online: January 15, 2017
Processing time: 117 Days and 4.2 Hours
Peer-review started: September 12, 2016
First decision: September 30, 2016
Revised: October 21, 2016
Accepted: November 16, 2016
Article in press: November 17, 2016
Published online: January 15, 2017
Processing time: 117 Days and 4.2 Hours
Core Tip
Core tip: Lower levels of undercarboxylated osteocalcin (OC) are found in diabetic patients as this hormone is involved in various glucorregulatory mechanisms; however evidence regarding its role in cardiovascular disease development is still pending. Here we show the correlation between levels of undercarboxylated OC and markers of cardiovascular risk.