Hami J, Shojae F, Vafaee-Nezhad S, Lotfi N, Kheradmand H, Haghir H. Some of the experimental and clinical aspects of the effects of the maternal diabetes on developing hippocampus. World J Diabetes 2015; 6(3): 412-422 [PMID: 25897352 DOI: 10.4239/wjd.v6.i3.412]
Corresponding Author of This Article
Hossein Haghir, MD, PhD, Department of Anatomy and Cell Biology, School of Medicine, Mashdad University of Medical Sciences, Azadi Square, Mashhad 91857, Iran. haghirh@mums.ac.ir
Research Domain of This Article
Developmental Biology
Article-Type of This Article
Review
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Hami J, Shojae F, Vafaee-Nezhad S, Lotfi N, Kheradmand H, Haghir H. Some of the experimental and clinical aspects of the effects of the maternal diabetes on developing hippocampus. World J Diabetes 2015; 6(3): 412-422 [PMID: 25897352 DOI: 10.4239/wjd.v6.i3.412]
Javad Hami, Fatemeh Shojae, Saeed Vafaee-Nezhad, Nasim Lotfi, Department of Anatomy, School of Medicine, Birjand University of Medical Sciences, Birjand 97178, Iran
Nasim Lotfi, Hossein Haghir, Department of Anatomy and Cell Biology, School of Medicine, Mashhad University of Medical Sciences, Mashhad 91857, Iran
Hamed Kheradmand, Hazrat Rasoul Hospital, Tehran University of Medical Sciences, Tehran 19168, Iran
Hossein Haghir, Medical Genetic Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad 91857, Iran
Author contributions: All authors contributed to this manuscript.
Conflict-of-interest: All authors claim no conflict of interest.
Correspondence to: Hossein Haghir, MD, PhD, Department of Anatomy and Cell Biology, School of Medicine, Mashdad University of Medical Sciences, Azadi Square, Mashhad 91857, Iran. haghirh@mums.ac.ir
Telephone: +98-513-8002486 Fax: +98-513-8002486
Received: August 27, 2014 Peer-review started: August 31, 2014 First decision: October 14, 2014 Revised: December 22, 2014 Accepted: January 9, 2015 Article in press: January 12, 2015 Published online: April 15, 2015 Processing time: 235 Days and 14.3 Hours
Core Tip
Core tip: Diabetes mellitus is the most seriously metabolic condition in pregnancy that affects the hippocampal development and function of the offspring. Multiple biological alterations, including hyperglycemia and hyperinsulinemia are occurring in maternal diabetes and impair the neurodevelopment of the fetus. Insulin-like growth factor-1 (IGF-1) and insulin are important regulators of development of central nervous system. It has clearly showed that maternal diabetes disturb the regulation of both insulin receptors and IGF-1 receptors in the hippocampus of rat newborn. This article is a brief review of the literatures that suggests a probable mechanism of how diabetes during pregnancy affects the hippocampus development in the offspring.
