©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Diabetes. Mar 15, 2015; 6(2): 326-332
Published online Mar 15, 2015. doi: 10.4239/wjd.v6.i2.326
Published online Mar 15, 2015. doi: 10.4239/wjd.v6.i2.326
Role of oxidative stress in endothelial insulin resistance
Francesco Paneni, Sarah Costantino, Francesco Cosentino, Cardiology Unit, Department of Medicine, Karolinska University Hospital, 17176 Stockholm, Sweden
Author contributions: Paneni F and Costantino S developed the concept and wrote the manuscript; Cosentino F revised the manuscript for important intellectual content.
Conflict-of-interest: The authors do not have any conflict of interest with regard to the present article.
Correspondence to: Francesco Paneni, MD, PhD, FESC, Cardiology Unit, Department of Medicine, Karolinska University Hospital, Solna, 17176 Stockholm, Sweden. francesco.paneni@ki.se
Telephone: +46-8-51779413 Fax: +46-8-344964
Received: September 22, 2014
Peer-review started: September 23, 2014
First decision: November 3, 2014
Revised: November 20, 2014
Accepted: December 29, 2014
Article in press: December 31, 2014
Published online: March 15, 2015
Processing time: 177 Days and 23.8 Hours
Peer-review started: September 23, 2014
First decision: November 3, 2014
Revised: November 20, 2014
Accepted: December 29, 2014
Article in press: December 31, 2014
Published online: March 15, 2015
Processing time: 177 Days and 23.8 Hours
Core Tip
Core tip: We present here the most recent advances in the understanding of endothelial insulin resistance, with a particular focus on the role of oxidative stress. The molecular pathways described may be instrumental for the development of mechanism-based therapeutic strategies to prevent maladaptive endothelial insulin signalling in patients with cardiometabolic disturbances.