From non-obese diabetic to Network for the Pancreatic Organ Donor with Diabetes: New heights in type 1 diabetes research

doi:10.4239/wjd.v6.i16.1309

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Nov 25, 2015 (publication date) through Mar 18, 2026

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World Journal of Diabetes

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Editorial

World J Diabetes. Nov 25, 2015; 6(16): 1309-1311
Published online Nov 25, 2015. doi: 10.4239/wjd.v6.i16.1309

From non-obese diabetic to Network for the Pancreatic Organ Donor with Diabetes: New heights in type 1 diabetes research

Lourdes Ramirez, Abdel Rahim A Hamad

Lourdes Ramirez, Abdel Rahim A Hamad, Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, United States

Author contributions: Ramirez L contributed to the writing and revising of the article; Hamad ARA conceived, designed and wrote the article.

Supported by The United States National Institutes of Health, No. 1R01AI099027 and 5R01DK104662 (to Hamad ARA).

Conflict-of-interest statement: The authors have no conflict of interests.

Correspondence to: Abdel Rahim A Hamad, BVSC, PhD, Associate Professor of Pathology and Medicine, Department of Pathology, Johns Hopkins University School of Medicine, 720 Rutland Ave, Ross 664G, Baltimore, MD 21205, United States. ahamad@jhmi.edu

Telephone: +1-410-6143021 Fax: +1-410-6143548

Received: July 8, 2015
Peer-review started: July 13, 2015
First decision: August 19, 2015
Revised: September 3, 2015
Accepted: November 3, 2015
Article in press: November 4, 2015
Published online: November 25, 2015
Processing time: 138 Days and 3.8 Hours

Core Tip

Core tip: Type 1 diabetes (T1D) strikes early in life with monumental impact on life style and long term health of affected children. There is currently no cure for T1D or mechanisms to protect at risk individuals. A major obstacle is the difficulty in translating the interventions that succeeded in preventing or reversing the disease in the non-obese diabetic mouse model into human immunotherapies. Network for the Pancreatic Organ Donor with Diabetes has been established in 2007 to study the disease directly in humans by procuring and offering well preserved tissues to investigators. These efforts, as indicated by published results, are paying off by providing critical new insights that are expected to facilitate development of efficacious immunotherapies.