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World J Diabetes. Dec 15, 2014; 5(6): 912-916
Published online Dec 15, 2014. doi: 10.4239/wjd.v5.i6.912
Published online Dec 15, 2014. doi: 10.4239/wjd.v5.i6.912
Possible contribution of (pro)renin receptor to development of gestational diabetes mellitus
Kanako Bokuda, Atsuhiro Ichihara, Department of Medicine II, Institute of Endocrinology and Hypertension, Tokyo Women’s Medical University, Tokyo 162-8666, Japan
Kanako Bokuda, Department of Internal Medicine, Keio University School of Medicine, Tokyo 160-8582, Japan
Author contributions: Bokuda K and Ichihara A contributed equally to this work and wrote the paper.
Correspondence to: Kanako Bokuda, MD, Department of Medicine II, Institute of Endocrinology and Hypertension, Tokyo Women’s Medical University, 8-1 Kawada-cho, Shinjuku-ku, Tokyo 162-8666, Japan. mkanakom31@yahoo.co.jp
Telephone: +81-3-33538111 Fax: +81-3-52697440
Received: July 24, 2014
Revised: August 21, 2014
Accepted: October 23, 2014
Published online: December 15, 2014
Processing time: 142 Days and 5 Hours
Revised: August 21, 2014
Accepted: October 23, 2014
Published online: December 15, 2014
Processing time: 142 Days and 5 Hours
Core Tip
Core tip: Prorenin receptor [(P)RR] binds (pro)renin, and leads to the activation of tissue renin-angiotensin system and intracellular signalings. It also plays an important role as vacuolar H+-ATPase associated protein, involving in Wnt signaling. Elevated plasma soluble (P)RR [s(P)RR] levels in the early stage of pregnancies are associated with higher incidence of gestational diabetes mellitus (GDM) during the third trimester. Also, elevated s(P)RR levels in cord blood, associated with a lower small for gestational age birth likelihood, suggesting the involvement of (P)RR in embryo’s growth. Here we attempt to elucidate the possible pathophysiological roles of the (P)RR in GDM.