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World J Diabetes. Feb 15, 2014; 5(1): 69-75
Published online Feb 15, 2014. doi: 10.4239/wjd.v5.i1.69
Published online Feb 15, 2014. doi: 10.4239/wjd.v5.i1.69
Starting glargine in insulin-naïve type 2 diabetic patients based on body mass index is safe
Denise R Franco, Juliana Baptista, Fatima RM Abreu, Risoneide B Batista, Freddy G Eliaschewitz, Medical Department, Clinical Research Center (CPCLIN), São Paulo 01244-030, Brazil
Denise R Franco, Associação do Diabetes Brazil (ADJ), São Paulo 05003-010, Brazil
Freddy G Eliaschewitz, Hospital Israelita Albert Einstein, São Paulo 05652-000, Brazil
Author contributions: Franco DR designed research, performed research, analyzed data and wrote the paper; Baptista J collected the data; Abreu FRM performed research; Batista RB performed research; Eliaschewitz FG designed research, performed research, analyzed data and wrote the paper.
Supported by Sanofi-Aventis Brazil
Correspondence to: Denise R Franco, MD, Medical Department, Clinical Research Center (CPCLIN), Rua Goias 193, São Paulo 01244-030, Brazil. d9franco@terra.com.br
Telephone: +55-119-82694700 Fax: +55-112-7110298
Received: August 5, 2013
Revised: October 21, 2013
Accepted: January 15, 2014
Published online: February 15, 2014
Processing time: 198 Days and 10 Hours
Revised: October 21, 2013
Accepted: January 15, 2014
Published online: February 15, 2014
Processing time: 198 Days and 10 Hours
Core Tip
Core tip: To start insulin therapy in insulin naïve type 2 diabetes patients, a long-acting basal insulin, such as insulin glargine, is added once a day. The majority of algorithms determine insulin titration according to fasting plasma glucose levels, but the dosage differs at the initial dose, frequency and speed of adjustments. It is difficult to compare the different algorithms employed in trials with populations of different socio-economic strata and variable access to educational materials. Here, we compared the safety of different titration algorithms in a population that was homogeneous in terms of socio-economic strata and with the same degree of education in diabetes.