Copyright
©2013 Baishideng Publishing Group Co., Limited. All rights reserved.
World J Diabetes. Dec 15, 2013; 4(6): 282-289
Published online Dec 15, 2013. doi: 10.4239/wjd.v4.i6.282
Published online Dec 15, 2013. doi: 10.4239/wjd.v4.i6.282
Therapeutic effects of sericin on diabetic keratopathy in Otsuka Long-Evans Tokushima Fatty rats
Noriaki Nagai, Yoshimasa Ito, Faculty of Pharmacy, Kinki University, Osaka 577-8502, Japan
Author contributions: Nagai N performed the research and analyzed the data; Nagai N and Ito Y wrote the paper.
Correspondence to: Yoshimasa Ito, PhD, Faculty of Pharmacy, Kinki University, Higashi-Osaka, Osaka 577-8502, Japan. itoyoshi@phar.kindai.ac.jp
Telephone: +81-6-43073638 Fax: +81-6-43073638
Received: September 14, 2013
Revised: October 19, 2013
Accepted: November 15, 2013
Published online: December 15, 2013
Processing time: 87 Days and 8.3 Hours
Revised: October 19, 2013
Accepted: November 15, 2013
Published online: December 15, 2013
Processing time: 87 Days and 8.3 Hours
Core Tip
Core tip: Otsuka Long-Evans Tokushima Fatty (OLETF) rats provide a useful model for studies to develop corneal wound healing drugs for use in diabetic keratopathy resulting from type 2 diabetes mellitus. The present study demonstrates that the rate of corneal wound healing in OLETF rats is slower than in normal rat, probably due to the suppression of cell migration and proliferation caused by high plasma glucose levels. The instillation of sericin has a potent effect in promoting wound healing and wound size reduction in OLETF rats. The sericin may be an effective and safe drug to promote corneal wound healing in diabetic keratopathy.