Jian-Guo Feng, PhD, Associate Professor, Principal Investigator, Department of Anesthesiology, The Affiliated Hospital, Southwest Medical University, No. 25 Taiping Street, Luzhou 646000, Sichuan Province, China. fengjianguo@swmu.edu.cn
Research Domain of This Article
Dermatology
Article-Type of This Article
editorial
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Chun-Yi Wu, Xie-Hua Xiao, Jian-Guo Feng, Department of Anesthesiology, The Affiliated Hospital, Southwest Medical University, Luzhou 646000, Sichuan Province, China
Co-first authors: Chun-Yi Wu and Xie-Hua Xiao.
Author contributions: Wu CY and Xiao XH contributed to writing-original draft, have made crucial and indispensable contributions towards the completion of the project and thus qualified as the co-first authors of the paper; Wu CY contributed to visualization and software; Feng JG contributed to conception and design of the study, manuscript review and editing; all authors contributed to the manuscript and approved the submitted version.
Supported by Sichuan Science and Technology Program, No. 2025ZNSFSC0744; Health Commission of Sichuan Province Medical Science and Technology Program, No. 24QNMP040; and Luzhou Science and Technology Program, No. 2025RCX002.
Conflict-of-interest statement: The authors declare no conflicts of interest.
Corresponding author: Jian-Guo Feng, PhD, Associate Professor, Principal Investigator, Department of Anesthesiology, The Affiliated Hospital, Southwest Medical University, No. 25 Taiping Street, Luzhou 646000, Sichuan Province, China. fengjianguo@swmu.edu.cn
Received: December 2, 2025 Revised: January 14, 2026 Accepted: February 4, 2026 Published online: September 15, 2026 Processing time: 272 Days and 21.8 Hours
Core Tip
Core Tip: This editorial highlight that fractional carbon dioxide (CO2) laser pre-conditioning offers a novel, drug-free strategy to enhance the therapeutic quality of adipose-derived mesenchymal stem cell exosomes (Exos) for diabetic wound repair. We emphasize recent findings that this physical pre-conditioning strategy, utilizing clinically established and dose-tunable photothermal stimulation, enriches sphingosine-1-phosphate (S1P) cargo and activates endothelial S1P receptor 1/protein kinase B/hypoxia-inducible factor-1α signaling, thereby promoting improved angiogenesis and cytoprotection. This concept reframes fractional CO2 lasers as a scalable, good manufacturing practice-compatible platform to “upgrade” Exos bioactivity for chronic diabetic wounds.
