Lu HL, Yu F, Zhou HF, Hu P, Gan SL. Clinical significance of bone metabolic markers in osteoporosis-complicated type 2 diabetes mellitus and risk determinants: A retrospective study. World J Diabetes 2026; 17(8): 123389 [DOI: 10.4239/wjd.123389]
Corresponding Author of This Article
Sheng-Lian Gan, Chief Physician, Department of Endocrinology and Metabolism, Changde Hospital, Xiangya School of Medicine, Central South University (The First People’s Hospital of Changde City), No. 388 Renmin East Road, Changde 415003, Hunan Province, China. ganshenglian03@126.com
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Endocrinology & Metabolism
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Lu HL, Yu F, Zhou HF, Hu P, Gan SL. Clinical significance of bone metabolic markers in osteoporosis-complicated type 2 diabetes mellitus and risk determinants: A retrospective study. World J Diabetes 2026; 17(8): 123389 [DOI: 10.4239/wjd.123389]
World J Diabetes. Aug 15, 2026; 17(8): 123389 Published online Aug 15, 2026. doi: 10.4239/wjd.123389
Clinical significance of bone metabolic markers in osteoporosis-complicated type 2 diabetes mellitus and risk determinants: A retrospective study
Hui-Lin Lu, Fang Yu, Hai-Feng Zhou, Ping Hu, Sheng-Lian Gan
Hui-Lin Lu, Fang Yu, Hai-Feng Zhou, Ping Hu, Sheng-Lian Gan, Department of Endocrinology and Metabolism, Changde Hospital, Xiangya School of Medicine, Central South University (The First People’s Hospital of Changde City), Changde 415003, Hunan Province, China
Author contributions: Lu HL participated in the study design, and wrote and revised the manuscript; Lu HL and Gan SL conducted the design of the study and reviewed/edited the drafts, and are guarantors; Lu HL, Yu F, Zhou HF, and Hu P collected and analyzed the data. All authors contributed to the article and approved the submitted article.
AI contribution statement: The authors declare that no AI tools were used in the development or writing of this manuscript and take full responsibility for its integrity, accuracy, and originality.
Institutional review board statement: This study was approved by the Ethic Committee of The First People’s Hospital of Changde City. No. 2026-298-01.
Informed consent statement: Due to the retrospective and de-identified nature of this study, written informed consent was waived.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: No additional data are available.
Corresponding author: Sheng-Lian Gan, Chief Physician, Department of Endocrinology and Metabolism, Changde Hospital, Xiangya School of Medicine, Central South University (The First People’s Hospital of Changde City), No. 388 Renmin East Road, Changde 415003, Hunan Province, China. ganshenglian03@126.com
Received: May 22, 2026 Revised: July 7, 2026 Accepted: July 31, 2026 Published online: August 15, 2026 Processing time: 74 Days and 22.8 Hours
Core Tip
Core Tip: Type 2 diabetes (T2DM) is associated with impaired bone quality and an increased risk of fractures. However, assessment based solely on bone density has important limitations. In this retrospective study, patients with T2DM and osteoporosis (OP) exhibited higher serum parathyroid hormone (PTH) and β-C-terminal telopeptide of type I collagen levels than those without OP, suggesting altered bone metabolism. Notably, PTH concentrations in the OP group were more than double those in the non-OP group and were accompanied by evidence of reduced skeletal responsiveness to PTH. Multivariate analysis further identified older age and elevated PTH levels as independent risk factors for OP comorbidity. These findings suggest that routine assessment of PTH and β-C-terminal telopeptide of type I collagen, combined with clinical evaluation, may facilitate the earlier identification of high-risk T2DM patients, thereby enabling early intervention before the occurrence of fragility fractures.
