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World J Diabetes. Jul 15, 2026; 17(7): 121202
Published online Jul 15, 2026. doi: 10.4239/wjd.121202
Published online Jul 15, 2026. doi: 10.4239/wjd.121202
Regulatory effects of Dangua Fang on the NAMPT/NAD+/SIRT1 axis and amino acid metabolism in type 2 diabetic rats
Zhuang Han, Zhi-Ta Wang, Liu-Qing Yang, Xian-Pei Heng, Department of Endocrinology, People’s Hospital Affiliated with Fujian University of Traditional Chinese Medicine, Fuzhou 350004, Fujian Province, China
Author contributions: Han Z and Heng XP designed the study; Han Z, Wang ZT, and Yang LQ performed the experiments; Han Z analyzed the data and wrote the manuscript; and all authors have read and approved the final manuscript.
AI contribution statement: AI tools (specifically ChatGPT) were used solely for linguistic refinement and formatting assistance. No AI tool was involved in the generation of research data, interpretation of results, or formulation of conclusions. All AI-generated outputs were critically reviewed and revised by the authors.
Supported by National Natural Science Foundation of China, No. 82274389 and No. 82205071.
Institutional animal care and use committee statement: All procedures involving animals were reviewed and approved by the Institutional Animal Care and Use Committee of Fujian University of Traditional Chinese Medicine, approval No. 2024072.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines.
Data sharing statement: The data supporting the findings of this study are available within the article. Further inquiries can be directed to the corresponding author.
Corresponding author: Xian-Pei Heng, MD, PhD, Professor, Chief Physician, Department of Endocrinology, People’s Hospital Affiliated with Fujian University of Traditional Chinese Medicine, No. 162 Bayiqi Middle Road, Taijiang District, Fuzhou 350004, Fujian Province, China. hengxianpei@hotmail.com
Received: March 18, 2026
Revised: May 12, 2026
Accepted: June 9, 2026
Published online: July 15, 2026
Processing time: 113 Days and 8.2 Hours
Revised: May 12, 2026
Accepted: June 9, 2026
Published online: July 15, 2026
Processing time: 113 Days and 8.2 Hours
Core Tip
Core Tip: This study demonstrated that Dangua Fang (DGF) ameliorated glucolipid metabolic disorders in type 2 diabetes mellitus rats. DGF reduced blood glucose and lipid levels and alleviated hepatic histopathological injury. These effects were accompanied by increased hepatic nicotinamide phosphoribosyltransferase, nicotinamide adenine dinucleotide, and sirtuin 1 expression. Metabolomic analysis further revealed that DGF significantly regulated abnormal hepatic amino acid metabolism in diabetic rats, which might be associated with modulation of the nicotinamide phosphoribosyltransferase/nicotinamide adenine dinucleotide/sirtuin 1 axis.