Assessment of the role of general control nonderepressible 2 in gestational diabetes mellitus progression and the underlying mechanisms

doi:10.4239/wjd.119780

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Publication Name

World Journal of Diabetes

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1948-9358

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Basic Study

Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Diabetes. Jul 15, 2026; 17(7): 119780
Published online Jul 15, 2026. doi: 10.4239/wjd.119780

Assessment of the role of general control nonderepressible 2 in gestational diabetes mellitus progression and the underlying mechanisms

Wan Li, Ya-Ru Wang, Shu-Li Wang

Wan Li, Ya-Ru Wang, Shu-Li Wang, Department of Gynecology and Obstetrics, Shenzhen Nanshan People’s Hospital, Shenzhen 518000, Guangdong Province, China

Author contributions: Li W, Wang YR and Wang SL designed the research study; Li W and Wang YR performed the research and wrote the manuscript; Wang YR analyzed the data; Li W and Wang SL supervised the study and acquired funding; Wang SL revised the manuscript; and all authors have read and approved the final manuscript.

AI contribution statement: The response to reviewers was not AI-generated. It was developed and reviewed by the authors. We used ChatGPT for language polishing.

Supported by Shenzhen Nanshan District Health Science and Technology Program Project, No. NS2023102; and Municipal Financial Subsidy of Nanshan District Medical Key Discipline Construction.

Institutional animal care and use committee statement: The study was reviewed and approved by the Animal Ethics Committee of the Guangdong Provincial Medical Laboratory Animal Center (Approval No. D202506-14).

Conflict-of-interest statement: The authors declare that they have no competing interests regarding the publication of this paper.

ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines.

Data sharing statement: The data used to support the findings of this study are available from the corresponding author upon request.

Corresponding author: Shu-Li Wang, MB, Research Fellow, Department of Gynecology and Obstetrics, Shenzhen Nanshan People’s Hospital, No. 89 Taoyuan Road, Nantou Street, Shenzhen 518000, Guangdong Province, China. sznsnancy@163.com

Received: February 6, 2026
Revised: March 31, 2026
Accepted: May 15, 2026
Published online: July 15, 2026
Processing time: 153 Days and 23.6 Hours

Core Tip

Core Tip: General control nonderepressible 2 is an important regulator of cellular stress responses, but its role in gestational diabetes mellitus remains unclear. This study demonstrates that it contributes to metabolic dysfunction and placental injury by modulating endoplasmic reticulum stress-associated mitochondrial dysfunction. Silencing this molecule alleviates oxidative stress and apoptosis while improving glucose and lipid metabolism. These findings suggest a potential mechanistic link between cellular stress and placental dysfunction and highlight a possible therapeutic target.