Glycemic status as a lens into heterogeneity of the obesity-cardiovascular risk in chronic kidney disease

doi:10.4239/wjd.117887

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World Journal of Diabetes

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1948-9358

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Diabetes. Jun 15, 2026; 17(6): 117887
Published online Jun 15, 2026. doi: 10.4239/wjd.117887

Glycemic status as a lens into heterogeneity of the obesity-cardiovascular risk in chronic kidney disease

Min Zhang, Kong-Rui Lu, Jun-Hao Han, Guo-Hua Gong

Min Zhang, Kong-Rui Lu, Jun-Hao Han, Guo-Hua Gong, School of Laboratory Medicine and Life Sciences, Wenzhou Medical University, Wenzhou 325035, Zhejiang Province, China

Author contributions: Zhang M wrote the manuscript; Han JH and Lu KR discussed and revised the text; Gong GH designed the study and revised the manuscript. All authors have read and approved the final manuscript.

Supported by the Medical Health Science and Technology Project of Zhejiang Provincial Health Commission, No. 2024KY138; the Basic Research Project of Wenzhou Municipal Science and Technology Bureau, No. Y20240008; and the Key Laboratory of School of Laboratory Medicine and Life Sciences, Wenzhou Medical University, No. JS2023003.

Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.

Corresponding author: Guo-Hua Gong, PhD, Professor, School of Laboratory Medicine and Life Sciences, Wenzhou Medical University, No. 82 West College Road, Wenzhou 325035, Zhejiang Province, China. guohgong@wmu.edu.cn

Received: December 18, 2025
Revised: February 2, 2026
Accepted: April 17, 2026
Published online: June 15, 2026
Processing time: 175 Days and 8 Hours

Core Tip

Core Tip: In patients with chronic kidney disease, there is a close relationship between cardiovascular risk and obesity indices, and blood glucose level is an important modulator of this relationship. Even in patients with a relatively low body weight, cardiovascular risk may be increased, challenging the notion that “thin is safe”. In clinical assessment, attention should be paid to both body mass index and waist circumference, along with evaluation of muscle atrophy and malnutrition, to enable individualized risk stratification.