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World J Diabetes. May 15, 2026; 17(5): 118333
Published online May 15, 2026. doi: 10.4239/wjd.v17.i5.118333
Published online May 15, 2026. doi: 10.4239/wjd.v17.i5.118333
When metabolic disease rewrites infection biology: Long-term multiorgan consequences of Helicobacter pylori infection in diabetes
Shree V Dhotre, Department of Microbiology, Ashwini Rural Medical College, Hospital and Research Centre, Solapur 413006, Maharashtra, India
Pradnya S Dhotre, Department of Biochemistry, Ashwini Rural Medical College, Hospital and Research Centre, Solapur 413001, Maharashtra, India
Arunkumar Rao, Department of Orthopedics, MIMSR Medical College, Latur 413512, India
Basavraj S Nagoba, Department of Microbiology, Maharashtra Institute of Medical Sciences and Research (Medical College), Latur 413531, Maharashtra, India
Author contributions: Nagoba BS conceptualized and designed the study, developed the study outline, and coordinated manuscript preparation; Nagoba BS, Dhotre SV, Dhotre PS, and Rao A made substantial contributions to the study design, data interpretation, and critical discussion of the manuscript; Dhotre SV and Nagoba BS drafted, critically revised, and edited the manuscript for important intellectual content and contributed to the literature review; and all authors approved the final version of the manuscript to be published.
AI contribution statement: Any language refinement during manuscript preparation was limited to minor grammatical or readability improvements, without involvement in content generation, data analysis, or drafting of the manuscript.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Corresponding author: Basavraj S Nagoba, PhD, Assistant Dean, Professor, Department of Microbiology, Maharashtra Institute of Medical Sciences and Research (Medical College), Vishwanathpuram, Ambajogai Road, Latur 413531, Maharashtra, India.
Received: December 30, 2025
Revised: February 11, 2026
Accepted: April 7, 2026
Published online: May 15, 2026
Processing time: 133 Days and 3.2 Hours
Revised: February 11, 2026
Accepted: April 7, 2026
Published online: May 15, 2026
Processing time: 133 Days and 3.2 Hours
Core Tip
Core Tip: This long-term experimental study demonstrates that diabetes transforms Helicobacter pylori infection from a largely gastric disease into a systemic pathological modifier. Prolonged colonization, persistent inflammation, extra-gastric dissemination of virulence factors, and compounded disruption of gut microbiota collectively drive irreversible multiorgan injury, even after partial improvement in bacterial load and glycemic status. These findings carry important implications for infection screening, eradication timing, and organ surveillance in diabetic patients, and open novel avenues for therapeutic intervention targeting the inflammation-microbiota-metabolic axis.