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Gastric electrical stimulation ameliorates antral myenteric neurons in streptozotocin-induced diabetic beagle canines
Pan Tang, Xin Wu, Ji-Ri Xi, Ming-Yu Fu, Xiao-Wei Xue, Ying Jiang, Yang Zhao, He-Er Yang, Gui-Jun Fei, Xiao-Qing Li, Chun-Hua Hu, Xiu-Cai Fang
Pan Tang, Ji-Ri Xi, Ming-Yu Fu, He-Er Yang, Gui-Jun Fei, Xiao-Qing Li, Xiu-Cai Fang, Department of Gastroenterology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China
Xin Wu, Department of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China
Xiao-Wei Xue, Ying Jiang, Department of Pathology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China
Yang Zhao, Department of Otorhinolaryngology – Head and Neck Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China
Chun-Hua Hu, School of Aerospace Engineering, Tsinghua University, Beijing 100084, China
Author contributions: Tang P analyzed the data and wrote the manuscript; Tang P, Fu MY, Xue XW, Jiang Y, Fei GJ, Li XQ, and Fang XC performed the experiments; Wu X, Xi JR, Zhao Y, Yang HE, and Hu CH conducted the surgery and research; Fang XC designed the study and critically revised the manuscript; all authors had final approval of the article.
Supported by National Key Technologies Research and Development Program of China, No. 2019YFC0118505.
Institutional animal care and use committee statement: All procedures involving animals were reviewed and approved by the Animal Welfare and Ethical Committee of Peking Union Medical College Hospital (No. XHDW-2020-047 and No. XHDW-2020-047-2).
Conflict-of-interest statement: All authors declare no conflict of interest in publishing the manuscript.
ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines.
Data sharing statement: The datasets generated or analyzed during the current study are available from the corresponding author upon reasonable request.
Corresponding author: Xiu-Cai Fang, Professor, Department of Gastroenterology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 1 Shuaifuyuan, Wangfujing, Dongcheng District, Beijing 100730, China.
fangxiucai2@aliyun.com
Received: December 1, 2025
Revised: January 20, 2026
Accepted: February 24, 2026
Published online: May 15, 2026
Processing time: 163 Days and 0.9 Hours
