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©The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Diabetes. Feb 15, 2026; 17(2): 116056
Published online Feb 15, 2026. doi: 10.4239/wjd.v17.i2.116056
Published online Feb 15, 2026. doi: 10.4239/wjd.v17.i2.116056
Decapping scavenger enzyme as a promising biomarker in diabetic foot ulcers: A need for cautious interpretation
Xiao-Ling Huang, Ying Wang, De-Fang Chen, Jin-Nian Duan, Ntim Michael, Bin Wang, Liaoning Provincial Key Laboratory of Cerebral Diseases, College of Basic Medical Sciences, National-Local Joint Engineering Research Center for Drug Research and Development of Neuro
Xiao-Ling Huang, Ying Wang, Yu-Song Ge, Department of Neurology, The Second Affiliated Hospital, Dalian Medical University, Dalian 116000, Liaoning Province, China
Rong Jiang, Department of Physiology, Binzhou Medical University, Yantai 264000, Shandong Province, China
Co-first authors: Xiao-Ling Huang and Ying Wang.
Co-corresponding authors: Yu-Song Ge and Bin Wang.
Author contributions: Huang XL and Wang Y contributed equally as co-first authors. They led the conceptualization and design of this letter, conducted the comprehensive literature review, synthesized the key insights, and drafted the manuscript. They also completed the initial and subsequent revisions, playing a central role in structuring the narrative, identifying critical issues, and ensuring that the discussion was both rigorous and thought-provoking; Chen DF, Jiang R and Duan JN made substantial contributions to literature screening and reference management. They assisted in organizing the manuscript framework, verified source validity, and refined key arguments to enhance clarity and coherence. They also provided valuable feedback during multiple rounds of revision, strengthening the overall logic and scholarly quality of the letter; Ge YS and Wang B served as co-corresponding authors and supervised the entire project. They offered essential intellectual guidance, ensured scientific rigor, and were closely involved in all stages of manuscript refinement. Their constructive critiques helped sharpen the argumentation and elevate the overall impact of the work. Additionally, Wang B facilitated institutional support and access to relevant research resources; this letter was completed through close collaboration among all authors; each made significant and indispensable contributions to the development, refinement, and finalization of the manuscript.
Supported by General Program of the Joint Fund Project under the Liaoning Provincial Science and Technology Plan, No. 2024-MSLH-104; and Natural Science Foundation of Shandong Province, No. ZR2022QH087.
Conflict-of-interest statement: The author reports no biomedical financial interests or potential conflicts of interest.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Bin Wang, PhD, Liaoning Provincial Key Laboratory of Cerebral Diseases, College of Basic Medical Sciences, National-Local Joint Engineering Research Center for Drug Research and Development of Neurodegenerative Diseases, Dalian Medical University, No. 9 West Section, Lvshun South Road, Dalian 116000, Liaoning Province, China. wb101900@126.com
Received: November 2, 2025
Revised: November 23, 2025
Accepted: December 10, 2025
Published online: February 15, 2026
Processing time: 97 Days and 15.9 Hours
Revised: November 23, 2025
Accepted: December 10, 2025
Published online: February 15, 2026
Processing time: 97 Days and 15.9 Hours
Core Tip
Core Tip: Decapping scavenger enzyme (DCPS), an N7-methylguanosine-related gene, has emerged as a potential diagnostic and therapeutic biomarker for diabetic foot ulcer (DFU) by linking RNA methylation to impaired keratinocyte function and wound repair. However, its variable expression, lack of standardized reference ranges, and uncertain therapeutic efficacy necessitate further validation. Future research should clarify DCPS’s regulatory mechanisms, develop clinical quantification standards, and assess targeted modulation to enhance its diagnostic precision and therapeutic potential in DFU.