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©The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Diabetes. Feb 15, 2026; 17(2): 115021
Published online Feb 15, 2026. doi: 10.4239/wjd.v17.i2.115021
Published online Feb 15, 2026. doi: 10.4239/wjd.v17.i2.115021
RRM2 attenuates renal tubular ferroptosis in diabetic kidney disease via the PI3K/Akt/Nrf2 pathway: Strengths, limitations, and future research directions
Ying-Chun Liu, Lin Chen, Department of Ultrasound, Huadong Hospital, Fudan University, Shanghai 200040, China
Jing Xiao, Department of Nephrology, Huadong Hospital, Fudan University, Shanghai 200040, China
Co-corresponding authors: Jing Xiao and Lin Chen.
Author contributions: Xiao J and Chen L contributed equally to this study as co-corresponding authors; Liu YC wrote the paper; Xiao J and Chen L edited the paper.
Conflict-of-interest statement: The authors declare they have no conflicts of interest to disclose.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Lin Chen, MD, PhD, Director, Department of Ultrasound, Huadong Hospital, Fudan University, No. 221 West Yan'an Road, Shanghai 200040, China.
Received: October 10, 2025
Revised: November 10, 2025
Accepted: December 15, 2025
Published online: February 15, 2026
Processing time: 120 Days and 8.2 Hours
Revised: November 10, 2025
Accepted: December 15, 2025
Published online: February 15, 2026
Processing time: 120 Days and 8.2 Hours
Core Tip
Core Tip: Against the backdrop of challenges in early diagnosis and prevention of the progression of diabetic kidney disease (DKD), with the key molecules involved in its underlying mechanisms remaining unclear, this study confirms the protective effect of ribonucleotide reductase M2 on DKD. This protective effect shows relevant implications for DKD research.