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Zhang YH, Song ZZ, Zhang S. Centrosome amplification in type 2 diabetes mellitus: Putative mechanisms, clinical research implications, and investigational therapeutic perspectives. World J Diabetes 2026; 17(11): 125802 [DOI: 10.4239/wjd.125802]
World J Diabetes. Nov 15, 2026; 17(11): 125802 Published online Nov 15, 2026. doi: 10.4239/wjd.125802
Centrosome amplification in type 2 diabetes mellitus: Putative mechanisms, clinical research implications, and investigational therapeutic perspectives
Yan-Hua Zhang, Zhi-Zhou Song, Sheng Zhang
Yan-Hua Zhang, Zhi-Zhou Song, Sheng Zhang, Department of Cardiology, The Third People’s Hospital of Datong, Datong 037000, Shanxi Province, China
Co-first authors: Yan-Hua Zhang and Zhi-Zhou Song.
Author contributions: Zhang YH and Song ZZ drafted the first version of the manuscript, contributed to conceptualization of this review, comprehensive literature retrieval and collation, construction of Table 1 and relevant schematic diagrams, manuscript revision, and preparation of replies to reviewer comments; they contributed equally to this article and are the co-first authors of this manuscript; Zhang S supervised the entire study and was responsible for the overall framework design of the review, critical revision of the manuscript, guidance for responding to reviewers, validation of the final manuscript, and acquisition of research funding; Zhang YH, Song ZZ, and Zhang S contributed to the study conception and design; and all authors thoroughly reviewed and endorsed the final manuscript.
AI contribution statement: AI-assisted tools were used for language editing and organizational support. All scientific content, references, interpretations, and revisions were independently verified and approved by the authors.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Corresponding author: Sheng Zhang, Chief Pharmacist, Department of Cardiology, The Third People’s Hospital of Datong, No. 43 Wenchang Street, Pingcheng District, Datong 037000, Shanxi Province, China. zhangshengxy3@csu.edu.cn
Received: July 17, 2026 Revised: August 15, 2026 Accepted: October 8, 2026 Published online: November 15, 2026 Processing time: 112 Days and 3.6 Hours
Core Tip
Core Tip: In vitro studies indicate that the diabetic microenvironment can induce Centrosome amplification (CA) via multiple interconnected signalling cascades, including protein kinase B-reactive oxygen species(Rho-associated coiled-coil-containing protein kinase 1/14-3-3 protein sigma, Wnt6-frizzled 4, protein kinase C-p38 and peroxisome proliferator-activated receptor γ-spindle and kinetochore-associated protein 1 axes. Putative links between CA and pancreatic β-cell failure, systemic insulin resistance, as well as diabetic macro-and microvascular complications remain largely hypothetical, owing to limited direct in vivo evidence from human metabolic tissues. Peripheral-blood-mononuclear-cell CA correlates with glycated haemoglobin and complication severity within a single observational clinical cohort; these associations cannot support prognostic inference, and it remains purely an exploratory research biomarker and is not ready for clinical application. Modulation of centrosome homeostasis represents a pre-clinical investigational direction; therapeutic benefits of polo-like kinase 4 inhibitors, Rho-associated coiled-coil-containing protein kinase blockers and antidiabetic agents related to CA suppression still await formal experimental verification.
