Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.
World J Diabetes. Oct 15, 2026; 17(10): 125822
Published online Oct 15, 2026. doi: 10.4239/wjd.125822
Published online Oct 15, 2026. doi: 10.4239/wjd.125822
Imbalances in RNA metabolic networks in vascular lesions associated with diabetes and sarcopenia
Lin-Yi Tang, The Key Laboratory of Medical Electrophysiology of the Ministry of Education, Laboratory of Nucleic Acids in Medicine for National High-Level Talents, Institute of Cardiovascular Research, Southwest Medical University, Luzhou 646000, Sichuan Province, China
Ting Huang, Department of Rehabilitation, The Affiliated Hospital of Southwest Medical University, Ministry of Education, Nucleic Acid Medicine of Luzhou Key Laboratory, Southwest Medical University, Luzhou 646000, Sichuan Province, China
Li-Yun Li, Yang Liu, Ping Yang, Hao-Ran Wu, Chun-Xiang Zhang, Department of Cardiology, The Affiliated Hospital, Southwest Medical University; Key Laboratory of Medical Electro
Zai-Yong Zheng, Department of Cardiology, Panzhihua Central Hospital, Panzhihua 617000, Sichuan Province, China
Co-first authors: Lin-Yi Tang and Ting Huang.
Co-corresponding authors: Hao-Ran Wu and Chun-Xiang Zhang.
Author contributions: Tang LY and Huang T contributed to the conceptualization of the study and software development, and wrote the original draft, they contributed equally to this article, they are the co-first authors of this manuscript; Li LY, Liu Y, Yang P, and Zheng ZY performed data curation; Li LY, Liu Y, Yang P, Zheng ZY, Wu HR, and Zhang CX were responsible for writing, review and editing of the manuscript; Wu HR and Zhang CX acquired funding and supervised the study, they contributed equally to this article, they are the co-corresponding authors of this manuscript; and all authors thoroughly reviewed and endorsed the final manuscript.
AI contribution statement: Portions of this manuscript were edited using AI tools solely for language refinement. The authors carefully reviewed and verified all AI-assisted outputs and take full responsibility for the scientific content of the manuscript.
Supported by National Natural Science Foundation of China, No. U23A20398; Health Commission of Sichuan Province Medical Science and Technology Program, No. 25QNMP060 and No. 25QNMP026; and Chengdu University of Traditional Chinese Medicine 2025 Joint University-Faculty Innovation Fund, No.XYLH202501024.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Corresponding author: Chun-Xiang Zhang, MD, PhD, Professor, Department of Cardiology, The Affiliated Hospital, Southwest Medical University; Key Laboratory of Medical Elec
Received: July 17, 2026
Revised: August 5, 2026
Accepted: September 28, 2026
Published online: October 15, 2026
Processing time: 87 Days and 18.3 Hours
Revised: August 5, 2026
Accepted: September 28, 2026
Published online: October 15, 2026
Processing time: 87 Days and 18.3 Hours
Core Tip
Core Tip: This article highlights that imbalances in RNA metabolism represent a key molecular link between diabetes, sarcopenia and vascular pathology. It emphasizes that non-coding RNA networks act as indispensable regulatory factors in the vascular damage caused by comorbidity, thereby providing new targets for precision therapy in the treatment of vascular pathology associated with comorbidity in older adults.