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World J Diabetes. Oct 15, 2026; 17(10): 125355
Published online Oct 15, 2026. doi: 10.4239/wjd.125355
Published online Oct 15, 2026. doi: 10.4239/wjd.125355
Association between estimated glucose disposal rate and metabolic dysfunction-associated steatotic liver disease in type 2 diabetes mellitus patients
Jian-Tong Yin, Yi-Xiao Lu, Zi-Meng Li, Department of Endocrinology, Hebei Medical University, Shijiazhuang 050011, Hebei Province, China
Jian-Tong Yin, Zi-Meng Li, Shu Niu, Department of Endocrinology, Shijiazhuang People’s Hospital, Shijiazhuang 050011, Hebei Province, China
Yi-Xiao Lu, Department of Endocrinology, The Fourth Hospital of Hebei Medical University, Hebei Medical University, Shijiazhuang 050011, Hebei Province, China
Author contributions: Yin JT and Niu S designed the research, performed data curation, formal analysis, and methodology development, as well as managed resources and utilized software, wrote the original draft of the manuscript; Lu YX and Li ZM reviewed and edited the manuscript to ensure its scientific rigor and clarity, contributing critical input in refining the final draft; and all authors thoroughly reviewed and endorsed the final manuscript.
AI contribution statement: The authors take full responsibility and accountability for all content of this manuscript, including any portions for which AI tools were used as assistive technologies. All AI-assisted outputs were carefully reviewed, validated, and approved by the authors. AI tools were not used to generate original scientific data, perform independent scientific analyses, or draw scientific conclusions.
Supported by 2024 Mandatory Research Projects of the Hebei Provincial Administration of Traditional Chinese Medicine, No. 2024127.
Institutional review board statement: This study was approved by the Medical Ethics Committee of Shijiazhuang People’s Hospital, approval No. 2024-177.
Informed consent statement: Written informed consent for publication was obtained from all patients and/or their families included in this study.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
STROBE statement: The authors have read the STROBE Statement-checklist of items, and the manuscript was prepared and revised according to the STROBE Statement-checklist of items.
Data sharing statement: The data sets generated and analyzed during this study are not public, but under reasonable requirements, the correspondence author can provide.
Corresponding author: Shu Niu, PhD, Department of Endocrinology, Shijiazhuang People’s Hospital, No. 36 Fanxi Road, Chang’an District, Shijiazhuang 050011, Hebei Province, China. niushu1007@126.com
Received: July 6, 2026
Revised: July 27, 2026
Accepted: September 20, 2026
Published online: October 15, 2026
Processing time: 100 Days and 0.2 Hours
Revised: July 27, 2026
Accepted: September 20, 2026
Published online: October 15, 2026
Processing time: 100 Days and 0.2 Hours
Core Tip
Core Tip: This cross-sectional study demonstrates that estimated glucose disposal rate is independently and inversely associated with metabolic dysfunction-associated steatotic liver disease risk in type 2 diabetes mellitus patients in a linear dose-dependent pattern. The association presents significant gender heterogeneity, being more pronounced in males. Estimated glucose disposal rate may serve as a simple practical indicator for metabolic dysfunction-associated steatotic liver disease risk stratification in clinical practice.