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World J Diabetes. Oct 15, 2026; 17(10): 124659
Published online Oct 15, 2026. doi: 10.4239/wjd.124659
Published online Oct 15, 2026. doi: 10.4239/wjd.124659
Elevated triglyceride-glucose index predicts poor third-trimester glycemic control among gestational diabetes mellitus women: A prospective study in Shanghai
Xiu-Qi Zhang, School of Medicine, Tongji University, Shanghai 200331, China
Xiu-Qi Zhang, Zhen Duan, Rui-Qi Cai, Xiang-Jin Gao, Rui Zhang, Rui-Ping Wang, Clinical Research Center, Shanghai Skin Diseases Hospital, Shanghai 200443, China
Cai-Xia Cheng, Department of Obstetrics and Gynecology, Songjiang Maternal and Children’s Health-Care Hospital, Shanghai 201620, China
Rui-Qi Cai, School of Public Health, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China
Qing Yang, Office of Public Health Management, Songjiang Maternal and Children’s Health-Care Hospital, Shanghai 201620, China
Co-first authors: Xiu-Qi Zhang and Cai-Xia Cheng.
Author contributions: Zhang XQ and Cheng CX drafted the manuscript, contributed equally to this study as co-first authors; Zhang XQ, Cheng CX, Duan Z and Cai RQ designed the study; Zhang XQ and Wang RP performed statistical analyses; Duan Z, Cai RQ, Gao XJ and Zhang R supervised the study; Gao XJ, Zhang R and Yang Q collected data; Wang RP revised the manuscript; all authors contributed to drafting and revising the manuscript and approved to submit the final version.
AI contribution statement: No AI tool was used to generate research data, interpret results, or formulate conclusions.
Supported by the Clinical Research Program of Shanghai Municipal Health Commission, No. 202240371; the Science and Technology Research Project in Songjiang District, No. 22SJKJGG53; the Clinical Research Plan of SHDC, No. SHDC2022CRS053 and No. SHDC2024CRX032; the Intelligence Fund of Shanghai Skin Diseases Hospital, No. 2021KYQD01; and the Shanghai Talent Development Fund, No. 2021073.
Institutional review board statement: The study was reviewed and approved by Institution Review Board of Songjiang Maternal and Children’s Health-Care Hospital (No. 2019-12-003).
Clinical trial registration statement: The study is registered at the Chinese Clinical Trial Registry. The registration identification number is ChiCTR2000028832. Details are available at https://www.chictr.org.cn/showproj.html?proj=47913.
Informed consent statement: All participants provided informed consent.
Conflict-of-interest statement: All authors declare no conflict of interest in publishing the manuscript.
CONSORT 2010 statement: The authors have read the CONSORT 2010 Statement, and the manuscript was prepared and revised according to the CONSORT 2010 Statement.
Data sharing statement: There is no additional data available.
Corresponding author: Rui-Ping Wang, MD, PhD, Chief Physician, Professor, Clinical Research Center, Shanghai Skin Diseases Hospital, No. 1278 Baode Road, Jing’an District, Shanghai 200443, China. w19830901@126.com
Received: June 26, 2026
Revised: July 20, 2026
Accepted: September 16, 2026
Published online: October 15, 2026
Processing time: 113 Days and 17.8 Hours
Revised: July 20, 2026
Accepted: September 16, 2026
Published online: October 15, 2026
Processing time: 113 Days and 17.8 Hours
Core Tip
Core Tip: The elevated triglyceride-glucose (TyG) index was negatively associated with good plasma glucose control in late pregnancy among women with gestational diabetes mellitus (GDM). TyG index less than 9.3 could predict good plasma glucose control in third trimester, particularly among GDM women with older age (≥ 35 years), and overweight/obesity [body mass index (BMI) ≥ 24 kg/m2]. In the future, measuring fasting plasma glucose and triglyceride levels in pregnant women with GDM at 24-28 gestational weeks and calculating TyG index, then this index could serve as an effective tool for predicting glycemic control status in late pregnancy among GDM women.