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World J Diabetes. Oct 15, 2026; 17(10): 124271
Published online Oct 15, 2026. doi: 10.4239/wjd.124271
Published online Oct 15, 2026. doi: 10.4239/wjd.124271
Clinical significance of serum thrombospondin-4 for interventional restenosis in diabetes patients complicated by lower extremity arteriosclerosis obliterans
Die Hu, Hua Ji, Ming-Wei Chen, Xiao-Tong Zhao, Department of Endocrinology, The First Affiliated Hospital of Anhui Medical University, Hefei 230032, Anhui Province, China
Xiao-Yue Lin, Department of General Practice, The First Affiliated Hospital of Anhui Medical University, Hefei 230032, Anhui Province, China
Tian-Qi Zhao, Department of Endocrinology, The Affiliated Chuzhou Hospital of Anhui Medical University, Chuzhou 239001, Anhui Province, China
Co-first authors: Die Hu and Xiao-Yue Lin.
Co-corresponding authors: Ming-Wei Chen and Xiao-Tong Zhao.
Author contributions: Hu D and Lin XY contributed to the conception and design of the study, they contributed equally to this article, they are the co-first authors of this manuscript; Hu D, Lin XY, Zhao TQ, and Ji H contributed to participant recruitment and clinical sample collection; Hu D, Lin XY, and Zhao XT performed data collection and analysis; Chen MW supervised the study and acquired funding; Chen MW and Zhao XT contributed equally to this article, they are the co-corresponding authors of this manuscript; and all authors reviewed and approved the final manuscript and agreed to its publication.
AI contribution statement: AI tools, specifically DeepSeek, were used solely for language polishing and formatting assistance. No AI tool was used to generate research data, interpret results, or formulate conclusions. All AI-assisted content was critically reviewed and revised by the authors, who take full responsibility for the accuracy, originality, and integrity of the manuscript.
Supported by the Clinical Medical Research Translation Special Project of Anhui Province in China, No. 202427b10020133; and the Anhui Provincial Health Research Project, No. AHWJ2023BAc10012.
Institutional review board statement: This study was approved by the Medical Ethics Committee of the First Affiliated Hospital of Anhui Medical University, approval No. PJ 2024-09-88.
Clinical trial registration statement: This study is registered at the Chinese Clinical Trial Registry (Registration ID: ChiCTR2500096943). Details are available at https://www.chictr.org.cn/bin/project/edit?pid=258670.
Informed consent statement: All study participants provided written consent prior to study enrollment.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
CONSORT 2010 statement: The authors have read the CONSORT 2010 Statement, and the manuscript was prepared and revised according to the CONSORT 2010 Statement.
Data sharing statement: There are no additional data available.
Corresponding author: Xiao-Tong Zhao, MD, Department of Endocrinology, The First Affiliated Hospital of Anhui Medical University, No. 218 Jixi Road, Hefei 230032, Anhui Province, China. zxt522154846@163.com
Received: June 11, 2026
Revised: July 20, 2026
Accepted: September 4, 2026
Published online: October 15, 2026
Processing time: 124 Days and 0.6 Hours
Revised: July 20, 2026
Accepted: September 4, 2026
Published online: October 15, 2026
Processing time: 124 Days and 0.6 Hours
Core Tip
Core Tip: In this prospective study on type 2 diabetes mellitus patients with lower extremity arteriosclerosis obliterans, after multivariable adjustment, serum thrombospondin-4 was found to be a new independent factor for restenosis, along with age and low-density lipoprotein cholesterol. The nomogram with these three variables, had strong discriminative power and good calibration, so it allows for earlier recognition of high risk patients and personalized interventions.