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World J Diabetes. Oct 15, 2026; 17(10): 124186
Published online Oct 15, 2026. doi: 10.4239/wjd.124186
Published online Oct 15, 2026. doi: 10.4239/wjd.124186
Hypertriglyceridemic acute pancreatitis with diabetes mellitus: Investigation of factors and predictive models for severity progression
Min Chai, Da-Hai Xu, Department of Emergency Medicine, The First Hospital of Jilin University, Changchun 130000, Jilin Province, China
Lian-Xi Zhao, Department of Neurology, The First Hospital of Jilin University, Changchun 130000, Jilin Province, China
Zhen-Gang Wang, Department of Spinal Surgery, Changchun Jirun Jingyue Hospital, Chang
Author contributions: Chai M wrote and edited the manuscript; Zhao LX and Wang ZG performed the manuscript; Xu DH designed and supervised the manuscript; and all authors have read and approved the final manuscript.
AI contribution statement: AI tools (specifically ChatGPT) were used solely for linguistic refinement and formatting assistance. No AI tool was involved in the generation of research data, interpretation of results, or formulation of conclusions. All AI-generated outputs were critically reviewed and revised by the authors.
Institutional review board statement: This study was approved by the Medical Ethics Committee of the First Hospital of Jilin University, approval No. 2024-865.
Informed consent statement: The informed consent was waived by the Institutional Review Board.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: Technical appendix, statistical code, and dataset available from the corresponding author at
Corresponding author: Da-Hai Xu, MD, Department of Emergency Medicine, The First Hospital of Jilin University, No. 1 Xinmin Street, Changchun 130000, Jilin Province, China. xudahai0319@jlu.edu.cn
Received: June 9, 2026
Revised: July 14, 2026
Accepted: August 31, 2026
Published online: October 15, 2026
Processing time: 126 Days and 0.8 Hours
Revised: July 14, 2026
Accepted: August 31, 2026
Published online: October 15, 2026
Processing time: 126 Days and 0.8 Hours
Core Tip
Core Tip: In a retrospective cohort of 133 patients with hypertriglyceridemic acute pancreatitis combined with diabetes mellitus, multivariate analysis revealed that heart rate, serum lipase, random plasma glucose, and pleural effusion were independent risk factors for severe disease, while albumin and platelets were protective. The predictive model incorporating these variables exhibited excellent discrimination (area under the curve = 0.894), good calibration, and net clinical benefit, aiding early risk stratification.