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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Diabetes. Sep 15, 2025; 16(9): 110515
Published online Sep 15, 2025. doi: 10.4239/wjd.v16.i9.110515
Published online Sep 15, 2025. doi: 10.4239/wjd.v16.i9.110515
Macrophage and inflammation in diabetes and metabolic dysfunction-associated steatotic liver disease: From mechanisms to therapeutic strategies
Chun-Ye Zhang, Bond Life Sciences Center, University of Missouri, Columbia, MO 65212, United States
Shuai Liu, The First Affiliated Hospital, Zhejiang University, Hangzhou 310006, Zhejiang Province, China
Ming Yang, Department of Surgery, University of Connecticut, School of Medicine, Far
Author contributions: Zhang CY, Liu S, and Yang M designed, wrote, revised, and finalized the manuscript.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Ming Yang, PhD, Assistant Professor, Department of Surgery, Uni
Received: June 9, 2025
Revised: July 8, 2025
Accepted: August 26, 2025
Published online: September 15, 2025
Processing time: 95 Days and 18.9 Hours
Revised: July 8, 2025
Accepted: August 26, 2025
Published online: September 15, 2025
Processing time: 95 Days and 18.9 Hours
Core Tip
Core Tip: Macrophages are an important cellular component that regulates metabolic disorders, including metabolic dysfunction-associated steatotic liver disease (MASLD) and type 2 diabetes (T2D). Macrophage-derived cytokines, chemokines, and metabolic products contribute to metabolic inflammation and insulin resistance, immune cell infiltration, and tissue injury. The phenotype and function of macrophages are important factors for evaluating the efficacy of MASLD and T2D treatments. Clinical trials are ongoing to dissect the roles of macrophages and test macrophage-targeted therapies in MASLD, T2D, and other related metabolic disorders.