Meta-Analysis
Copyright ©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Diabetes. May 15, 2025; 16(5): 103403
Published online May 15, 2025. doi: 10.4239/wjd.v16.i5.103403
Increased colorectal cancer risk in prediabetes: A meta-analysis
Na Wang, Tian-Yi Zhao, Xiao Ma
Na Wang, Tian-Yi Zhao, Xiao Ma, Physical Examination Center, China-Japan Friendship Hospital, Beijing 100029, China
Author contributions: Wang N contributed to conceptualization, formal analysis, methodology, software, and wrote original draft; Wang N and Zhao TY performed data curation and investigation; Ma X contributed to funding acquisition and supervision; Wang N, Zhao TY, and Ma X reviewed and edited the manuscript.
Supported by National High Level Hospital Clinical Research Funding, No. 2023-NHLHCRF-YXHZ-ZRMS-06.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Xiao Ma, MD, Physical Examination Center, China-Japan Friendship Hospital, No. 47 Wenxueguan Road, Chaoyang District, Beijing 100029, China. redapple3155@qq.com
Received: November 19, 2024
Revised: January 21, 2025
Accepted: February 21, 2025
Published online: May 15, 2025
Processing time: 157 Days and 17.4 Hours
Core Tip

Core Tip: Previous research yielded conflicting results regarding the association between prediabetes and colorectal cancer (CRC). We conducted a meta-analysis to systematically assess the incidence of CRC in individuals with prediabetes compared with those with normoglycemia. A significant 18% increase in the occurrence of CRC among individuals with prediabetes compared with those with normoglycemia was observed. These results suggested that people with prediabetes have a higher likelihood of developing CRC than those with normoglycemia.