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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Diabetes. Mar 15, 2025; 16(3): 92003
Published online Mar 15, 2025. doi: 10.4239/wjd.v16.i3.92003
Published online Mar 15, 2025. doi: 10.4239/wjd.v16.i3.92003
LEF1 influences diabetic retinopathy and retinal pigment epithelial cell ferroptosis via the miR-495-3p/GRP78 axis through lnc-MGC
Yi-Yi Luo, Xue-Ying Ba, Jian Han, Heng Luo, Precision Medicine Center of Chuxiong Yi Autonomous Prefecture, The People's Hospital of Chuxiong Yi Autonomous Prefecture & The Fourth Affiliated Hospital of DaLi University, Chuxiong 675000, Yunnan Province, China
Ling Wang, Pei-Qi Chen, Department of Endocrinology, The People's Hospital of Chuxiong Yi Autonomous Prefecture & The Fourth Affiliated Hospital of DaLi University, Chuxiong 675000, Yunnan Province, China
Ye-Pin Zhang, Department of Pathology, The People's Hospital of Chuxiong Yi Autonomous Prefecture & The Fourth Affiliated Hospital of DaLi University, Chuxiong 675000, Yunnan Province, China
Hong Xu, Li-Bo Zhang, Heng Luo, Department of Ophthalmology, The People's Hospital of Chuxiong Yi Autonomous Prefecture & The Fourth Affiliated Hospital of DaLi University, Chuxiong 675000, Yunnan Province, China
Co-first authors: Yi-Yi Luo and Xue-Ying Ba.
Author contributions: Luo YY and Ba XY contributed equally to this work as co-first authors; Luo YY, Ba XY, Wang L, Zhang YP, Luo H were responsible for conceptualization, methodology, validation, formal analysis, investigation, data curation, writing-original draft, writing-review and editing; Xu H was responsible for project administration; Chen PQ was responsible for resources; Zhang LB and Han J were responsible for resources, software, formal analysis; all the authors have read and approved the final manuscript.
Supported by Science and Technology Program of Yunnan Provincial Department of Science and Technology-Basic Research Program, No. 202301BA070001-025.
Institutional review board statement: This study was reviewed and approved by the People's Hospital of Chuxiong Yi Autonomous Prefecture (2022-10).
Institutional animal care and use committee statement: All procedures involving animals were reviewed and approved by the Institutional Animal Care and Use Committee of the People's Hospital of Chuxiong Yi Autonomous Prefecture (2022-10).
Conflict-of-interest statement: The authors have no conflicts of interest to declare.
Data sharing statement: No additional data are available.
ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Heng Luo, MD, Department of Ophthalmology, The People's Hospital of Chuxiong Yi Autonomous Prefecture & The Fourth Affiliated Hospital of DaLi University, No. 318 Lucheng South Road, Chuxiong 675000, Yunnan Province, China.
Received: January 12, 2024
Revised: November 10, 2024
Accepted: December 11, 2024
Published online: March 15, 2025
Processing time: 375 Days and 6.6 Hours
Revised: November 10, 2024
Accepted: December 11, 2024
Published online: March 15, 2025
Processing time: 375 Days and 6.6 Hours
Core Tip
Core Tip: Inhibiting lnc-MGC protects retinal pigment epithelium cells from high glucose-induced apoptosis, inflammation and oxidative stress. Lnc-MGC targeted miR-495-3p and miR-495-3p targeted GRP78. Lnc-MGC regulated endoplasmic reticulum stress and ferroptosis via miR-495-3p/GRP78. LEF1 regulated diabetic retinopathy as binding protein of lnc-MGC.