©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Diabetes. Mar 15, 2025; 16(3): 101488
Published online Mar 15, 2025. doi: 10.4239/wjd.v16.i3.101488
Published online Mar 15, 2025. doi: 10.4239/wjd.v16.i3.101488
Triglyceride-glucose related indices as predictors for major adverse cardiovascular events and overall mortality in type-2 diabetes mellitus patients
Mao-Jun Liu, Jun-Yu Pei, Cheng Zeng, Ying Xing, Yi-Feng Zhang, Pei-Qi Tang, Si-Min Deng, Xin-Qun Hu, Department of Cardiovascular Medicine, The Second Xiangya Hospital, Central South University, Changsha 410011, Hunan Province, China
Author contributions: Hu XQ and Liu MJ designed the study; Hu XQ, Liu MJ and Pei JY prepared the manuscript; Zeng C, Xin Y, Zhang YF, Tang PQ and Deng SM revised the draft; All authors read and approved the final manuscript.
Institutional review board statement: The study was exempt from ethical review and approval, as no additional institutional review board approval was necessary for the secondary analysis.
Informed consent statement: The data for our study are derived from the Action to Control Cardiovascular Risk in Diabetes (ACCORD). All participants completed informed consent forms before participating in the study.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: The original data are available from the NHLBI BioLINCC. Some or all of the data sets generated and/or analyzed in the current study are not publicly available, but may be obtained from the corresponding author upon reasonable request at huxinqun@csu.edu.cn.
Corresponding author: Xin-Qun Hu, MD, Chief Physician, Professor, Department of Cardio
Received: September 16, 2024
Revised: November 5, 2024
Accepted: December 26, 2024
Published online: March 15, 2025
Processing time: 127 Days and 2.6 Hours
Revised: November 5, 2024
Accepted: December 26, 2024
Published online: March 15, 2025
Processing time: 127 Days and 2.6 Hours
Core Tip
Core Tip: This study demonstrates that triglyceride-glucose-related indices, namely the triglyceride glucose (TyG)-waist height ratio (WHtR) and TyG-waist circumference (TyG-WC), are significant predictors of major adverse cardiovascular events (MACEs) and overall mortality in patients with type 2 diabetes mellitus (T2DM). Including TyG-WHtR and TyG-WC in conventional cardiovascular risk models significantly improves predictive accuracy for MACEs and mortality. These indices could be valuable for early cardiovascular risk stratification and targeted intervention in T2DM management.