Retrospective Cohort Study
Copyright ©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Diabetes. Feb 15, 2025; 16(2): 101779
Published online Feb 15, 2025. doi: 10.4239/wjd.v16.i2.101779
Impact of setting distinct target blood glucose levels on endogenous insulin suppression and pharmacodynamics of insulin preparations
Hui Liu, Ting Li, Xin-Lei Chen, Hong-Ling Yu, Ye-Rong Yu
Hui Liu, Xin-Lei Chen, Hong-Ling Yu, Ye-Rong Yu, Department of Endocrinology and Metabolism, West China Hospital of Sichuan University, Chengdu 610041, Sichuan Province, China
Hui Liu, Clinical Trial Center, West China Hospital of Sichuan University, Chengdu 610041, Sichuan Province, China
Ting Li, Health Management Center, General Practice Medical Center, West China Hospital of Sichuan University, Chengdu 610041, Sichuan Province, China
Author contributions: Liu H and Yu YR designed the research study; Liu H, Li T, Chen XL, and Yu HL performed the research; Liu H and Yu YR analyzed the data and wrote the manuscript; all authors have read and approved the final manuscript.
Institutional review board statement: The study was reviewed and approved by the ethics committee of West China Hospital of Sichuan University.
Informed consent statement: Written informed consent was obtained from all participants.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: No additional data are available.
STROBE statement: The authors have read the STROBE Statement—checklist of items, and the manuscript was prepared and revised according to the STROBE Statement—checklist of items.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Ye-Rong Yu, MD, Chief Doctor, Professor, Department of Endocrinology and Metabolism, West China Hospital of Sichuan University, No. 37 Guoxue Alley, Wuhou District, Chengdu 610041, Sichuan Province, China. yerongyu@scu.edu.cn
Received: September 26, 2024
Revised: November 15, 2024
Accepted: December 5, 2024
Published online: February 15, 2025
Processing time: 95 Days and 1.3 Hours
Core Tip

Core Tip: Insulin therapy is of great importance in anti-diabetes treatment. This study focuses on the preclinical assessment of insulin preparation using the euglycemic clamp technique in healthy subjects. Typically, blood glucose is usually maintained below the individual’s baseline throughout the clamp to inhibit endogenous insulin secretion. The hypoglycemic risk would increase if the BG baseline is relatively low. This retrospective cohort study enrolled euglycemic clamp trials evaluating the pharmacokinetics and pharmacodynamics of insulin aspart to explore optimal methodologies for conducting euglycemic clamps under these circumstances.