Huang BJ, Guo S, Lin XY, Li YH, Ma HM, Zhang J, Chen QL. Oral Akkermansia muciniphila may ameliorates immune dysregulation in a murine model of streptozotocin-induced type 1 diabetes. World J Diabetes 2025; 16(12): 111771 [DOI: 10.4239/wjd.v16.i12.111771]
Corresponding Author of This Article
Qiu-Li Chen, MD, Doctor, Department of Pediatrics, The First Affiliated Hospital, Sun Yat-sen University, No. 58 Zhongshan Second Road, Guangzhou 510000, Guangdong Province, China. chenqiul@mail.sysu.edu.cn
Research Domain of This Article
Pediatrics
Article-Type of This Article
Basic Study
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This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Dec 15, 2025 (publication date) through Dec 15, 2025
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Journal Information of This Article
Publication Name
World Journal of Diabetes
ISSN
1948-9358
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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
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Huang BJ, Guo S, Lin XY, Li YH, Ma HM, Zhang J, Chen QL. Oral Akkermansia muciniphila may ameliorates immune dysregulation in a murine model of streptozotocin-induced type 1 diabetes. World J Diabetes 2025; 16(12): 111771 [DOI: 10.4239/wjd.v16.i12.111771]
World J Diabetes. Dec 15, 2025; 16(12): 111771 Published online Dec 15, 2025. doi: 10.4239/wjd.v16.i12.111771
Oral Akkermansia muciniphila may ameliorates immune dysregulation in a murine model of streptozotocin-induced type 1 diabetes
Bao-Jiang Huang, Song Guo, Xiao-Ya Lin, Yan-Hong Li, Hua-Mei Ma, Jun Zhang, Qiu-Li Chen
Bao-Jiang Huang, Song Guo, Xiao-Ya Lin, Yan-Hong Li, Hua-Mei Ma, Jun Zhang, Qiu-Li Chen, Department of Pediatrics, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510000, Guangdong Province, China
Co-first authors: Bao-Jiang Huang and Song Guo.
Co-corresponding authors: Jun Zhang and Qiu-Li Chen.
Author contributions: Huang BJ and Guo S contributed to the manuscript writing and editing, and review of literature as co-first authors; Zhang J and Chen QL designed the overall concept and outline of the manuscript; Lin XY, Li YH and Ma HM contributed to the discussion and design of the manuscript; all authors contributed to finalizing the manuscript.
Institutional review board statement: This study does not involve any human experiments.
Institutional animal care and use committee statement: All procedures involving animals were reviewed and approved by the the Institutional Animal Care and Use Committee of Sun Yat-sen University (No. 2023001513).
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines.
Data sharing statement: The data used to support the findings of this study are included within the article.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Qiu-Li Chen, MD, Doctor, Department of Pediatrics, The First Affiliated Hospital, Sun Yat-sen University, No. 58 Zhongshan Second Road, Guangzhou 510000, Guangdong Province, China. chenqiul@mail.sysu.edu.cn
Received: July 9, 2025 Revised: August 6, 2025 Accepted: November 13, 2025 Published online: December 15, 2025 Processing time: 159 Days and 16.6 Hours
Core Tip
Core Tip: This study pioneers Akkermansia muciniphila (A. muciniphila) intervention evaluation in streptozotocin-induced type 1 diabetes mellitus (T1DM) mice. Despite no reversal of hyperglycemia or islet damage after short-term (3-day) oral administration, A. muciniphila ameliorated immune imbalance by enhancing intestinal barrier function (increased zonula occludens-1, decreased zonulin), suppressing pro-inflammatory cytokines (tumor necrosis factor-alpha, interferon-gamma), increasing anti-inflammatory interleukin-4 and regulatory T cells, modulating signaling pathways (reduced signal transducer and activator of transcription 1, suppressed nuclear factor kappa-B p65), and decreasing intestinal Actinobacteria abundance. These findings highlight A. muciniphila’s potential for immune regulation in established T1DM by gut barrier repair and microbial shifts.
