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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Diabetes. Dec 15, 2025; 16(12): 110494
Published online Dec 15, 2025. doi: 10.4239/wjd.v16.i12.110494
Published online Dec 15, 2025. doi: 10.4239/wjd.v16.i12.110494
Impact of diabetes mellitus on mortality and atrial fibrillation in hypertrophic cardiomyopathy: A systematic review and meta-analysis
Nanush Damarlapally, Department of Health Sciences, Houston Community College-Coleman Campus, Houston, TX 77030, United States
Roopeessh Vempati, Department of Internal Medicine, Trinity Health Oakland Hospital, Pontiac, MI 48341, United States
Kesha Mayank Doshi, Department of Medicine, Byramjee Jeejeebhoy Medical College, Ahmedabad 380016, India
Manavjot Singh, Department of Medicine, Dayanand Medical College, Ludhiana 141001, Punjab, India
Kesar Prajapati, Department of Internal Medicine, Metropolitan Hospital Center, New York City Health and Hospitals Corporation, New York, NY 10029, United States
Dhruvi Modi, Department of Internal Medicine, Gujarat Adani Institute of Medical Sciences, Bhuj 370001, Gujarat, India
Pooja Singh, Department of Internal Medicine, Multicare Tacoma General Hospital, Tacoma, WA 98405, United States
Rupak Desai, Independent Researcher, Atlanta, GA 30079, United States
Co-first authors: Nanush Damarlapally and Roopeessh Vempati.
Author contributions: Damarlapally N and Vempati R contributed equally to this work as co-first authors, conceptualized and designed the study, developed the methodology, performed data curation and formal analysis, drafted the original manuscript, and supervised the project; Doshi KM and Singh M contributed to methodology, performed data extraction, assisted with statistical interpretation, and participated in reviewing and editing the manuscript; Prajapati K and Modi D contributed to data collection and curation and participated in manuscript drafting and critical revision; Singh P assisted with data organization and manuscript review and editing; Desai R provided senior oversight, validated the analysis, contributed to the editing of the manuscript, and supervised the overall project administration. All authors have read and approved the final manuscript.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Rupak Desai, MBBS, Independent Researcher, Scottdale, Atlanta, GA 30079, United States. drrupakdesai@gmail.com
Received: June 9, 2025
Revised: July 28, 2025
Accepted: November 3, 2025
Published online: December 15, 2025
Processing time: 190 Days and 15.2 Hours
Revised: July 28, 2025
Accepted: November 3, 2025
Published online: December 15, 2025
Processing time: 190 Days and 15.2 Hours
Core Tip
Core Tip: This meta-analysis evaluated the impact of diabetes mellitus (DM) on clinical outcomes in patients with hypertrophic cardiomyopathy (HCM), focusing on all-cause mortality and atrial fibrillation. The findings underscore the importance of recognizing DM as a modifier of adverse outcomes in HCM, particularly due to its contribution to arrhythmias and cardiac dysfunction. The included studies had a low risk of bias, and sensitivity analyses confirmed the robustness of the results. Clinicians should consider more aggressive glycemic and cardiovascular risk factor control in HCM patients with comorbid diabetes to reduce preventable complications and improve long-term outcomes. This study fills a crucial gap in evidence linking DM to poor prognosis in HCM.