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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Diabetes. Oct 15, 2025; 16(10): 110097
Published online Oct 15, 2025. doi: 10.4239/wjd.v16.i10.110097
Published online Oct 15, 2025. doi: 10.4239/wjd.v16.i10.110097
MicroRNA 375 and diabetes: A key regulator of β cell function and a promising non-invasive biomarker
Marina Pierantoni, Marcello Dell’Aira, Federica Brugnoli, Valeria Bertagnolo, Department of Translational Medicine, University of Ferrara, Ferrara 44121, Italy
Silvia Grassilli, Department of Environmental and Prevention Sciences, University of Ferrara, Ferrara 44121, Italy
Silvia Grassilli, Laboratory for Advanced Therapy Technologies Centre, University of Ferrara, Ferrara 44121, Italy
Author contributions: Pierantoni M conducted the literature review, created the artwork and wrote the original draft; Pierantoni M and Brugnoli F interpreted data; Dell’Aira M and Grassilli S performed the literature analysis; Dell’Aira M, Grassilli S, and Brugnoli F drafted the original manuscript; Bertagnolo V conceptualized, designed and supervised the study and reviewed the original manuscript. All authors have approved the submitted version.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Federica Brugnoli, PhD, Researcher, Department of Translational Me
Received: May 29, 2025
Revised: June 23, 2025
Accepted: September 18, 2025
Published online: October 15, 2025
Processing time: 139 Days and 18.2 Hours
Revised: June 23, 2025
Accepted: September 18, 2025
Published online: October 15, 2025
Processing time: 139 Days and 18.2 Hours
Core Tip
Core Tip: Diabetes mellitus is strongly linked to microRNA 375 (miR-375), the most abundant miRNA in pancreatic β cells, where it plays an essential role in cell development and insulin production. MiR-375 is detectable in blood, making it a promising non-invasive biomarker, but the exact relationship between circulating miR-375 levels and both type 1 diabetes and type 2 diabetes remains unclear. This review provides a comprehensive overview of the current understanding of how miR-375 contributes to the onset and progression of diabetes mellitus and its potential use as a tool for the management of this complex pathology.