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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Diabetes. Oct 15, 2025; 16(10): 107640
Published online Oct 15, 2025. doi: 10.4239/wjd.v16.i10.107640
Published online Oct 15, 2025. doi: 10.4239/wjd.v16.i10.107640
Epicardial adipose tissue in diabetic myocardial disorder: Role of echocardiography
Ana Đuzel Čokljat, Damir Čokljat, Jerko Ferri Certić, Department of Internal Medicine, General Hospital Dubrovnik, Dubrovnik 20000, Croatia
Petra Grubić Rotkvić, Department of Cardiology, University Hospital Centre Zagreb, Zagreb 10000, Croatia
Zdravko Babić, Department of Cardiology, University Hospital Centre Sestre Milosrdnice, Zagreb 10000, Croatia
Co-corresponding authors: Ana Đuzel Čokljat and Petra Grubić Rotkvić.
Author contributions: Đuzel Čokljat A wrote the original draft, designed the study, and performed the literature search; Grubić Rotkvić P analyzed the data, and reviewed and edited the manuscript; Čokljat D and Ferri Certić J performed the literature search and reviewed the manuscript; Babić Z designed and supervised the study; All authors have read and approved the final manuscript.
Conflict-of-interest statement: The authors have no conflicts of interest to declare.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Ana Đuzel Čokljat, MD, Department of Internal Medicine, General Hospital Dubrovnik, Ulica dr. Roka Mišetića 2, Dubrovnik 20000, Croatia.
Received: March 27, 2025
Revised: May 14, 2025
Accepted: August 4, 2025
Published online: October 15, 2025
Processing time: 202 Days and 15.3 Hours
Revised: May 14, 2025
Accepted: August 4, 2025
Published online: October 15, 2025
Processing time: 202 Days and 15.3 Hours
Core Tip
Core Tip: Epicardial adipose tissue (EAT), as measured by two-dimensional echo, provides additional information for the assessment of diabetic myocardial disorder. It may serve as a novel tool for risk estimation of the progression from asymptomatic to symptomatic heart failure. Given its rapid metabolic activity, EAT may serve as a target for existing and emerging therapies. The proposed cardiovascular benefits of EAT lipolysis in the context of diabetes mellitus type 2 could help clarify the mechanisms underlying its therapeutic modulation. Excessive EAT can be regarded, de facto, as an indicator of diabetic pericardial disorder.