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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Diabetes. Jan 15, 2025; 16(1): 100066
Published online Jan 15, 2025. doi: 10.4239/wjd.v16.i1.100066
Published online Jan 15, 2025. doi: 10.4239/wjd.v16.i1.100066
Enhancing metformin efficacy with cholecalciferol and taurine in diabetes therapy: Potential and limitations
Gehan El-Akabawy, Department of Basic Medical Sciences, College of Medicine, Ajman University, Ajman 346, United Arab Emirates
Nabil Eid, Department of Anatomy, Division of Human Biology, School of Medicine, IMU University, Kuala Lumpur 57000, Malaysia
Author contributions: El-Akabawy G wrote the manuscript; Eid N wrote, revised, and approved the final draft.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Nabil Eid, MD, PhD, Academic Editor, Affiliate Associate Professor, Doctor, Senior Lecturer, Department of Anatomy, Division of Human Biology, School of Medicine, IMU University, Bukit Jalil, Kuala Lumpur 57000, Malaysia.
Received: August 7, 2024
Revised: November 4, 2024
Accepted: November 15, 2024
Published online: January 15, 2025
Processing time: 115 Days and 19 Hours
Revised: November 4, 2024
Accepted: November 15, 2024
Published online: January 15, 2025
Processing time: 115 Days and 19 Hours
Core Tip
Core Tip: Diabetes mellitus, particularly type 2 diabetes mellitus (T2DM), poses a significant global health problem. Metformin is commonly used to control hyperglycemia linked to T2DM. Supplementing metformin with cholecalciferol (vitamin D3) and taurine can mitigate diabetes-related complications in a rat model of T2DM by reducing oxidative stress, inflammation, and lipid abnormalities. These findings suggest a synergistic effect between metformin, cholecalciferol, and taurine in managing T2DM complications, potentially offering a more holistic approach to diabetes care.