Basic Study
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Diabetes. Sep 15, 2024; 15(9): 1916-1931
Published online Sep 15, 2024. doi: 10.4239/wjd.v15.i9.1916
Corilagin alleviates podocyte injury in diabetic nephropathy by regulating autophagy via the SIRT1-AMPK pathway
Yu Lou, Yu-Ting Luan, Wen-Qing Rong, Yun Gai
Yu Lou, Department of Preventive Treatment of Disease, Seventh People's Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 200137, China
Yu-Ting Luan, Department of Infectious Diseases, Seventh People's Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 200137, China
Wen-Qing Rong, Yun Gai, Department of General Practice (Including Medical Oncology), Seventh People's Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 200137, China
Author contributions: Lou Y and Luan YT performed conceptualization, methodology, data curation, visualization, investigation, and writing of the original draft; Rong WQ was responsible for project administration; Gai Y was responsible for supervision, funding acquisition, resources, and review and editing of the manuscript. Lou Y and Luan YT contributed equally to this work.
Supported by Shanghai Pudong New Area Leading Talents Training Program Project, No. PWR12020-02; Shanghai Pudong New Area Excellent Young Medical Talents Training Program Project, No. PWRq2023-40; and Shanghai Pudong New Area Health and Family Planning Scientific Research Project, No. PW2022A-91.
Institutional review board statement: This study was reviewed and approved by the Ethics Committee of Shanghai Seventh People’s Hospital of Shanghai University of Traditional Chinese Medicine.
Institutional animal care and use committee statement: The Animal Care and Use Committee of Shanghai Seventh People’s Hospital of Shanghai University of Traditional Chinese Medicine approved this entire study.
Conflict-of-interest statement: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
Data sharing statement: The datasets used and/or analyzed during the current study are available from the corresponding author on reasonable request.
ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Yun Gai, PhD, Chief Physician, Department of General Practice (Including Medical Oncology), Seventh People's Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, No. 358 Datong Road, Shanghai 200137, China. gaiyunlucky@163.com
Received: March 6, 2024
Revised: June 4, 2024
Accepted: July 2, 2024
Published online: September 15, 2024
Processing time: 174 Days and 4 Hours
Core Tip

Core Tip: This study explored the protective effects of Corilagin (Cor) against podocyte injury in diabetic nephropathy (DN). Cor treatment markedly attenuated fasting blood glucose, glycosylated hemoglobin, triglycerides, and total cholesterol, increased nephrin and podocin expression, reduced apoptosis rate, and inhibited inflammatory cytokines and oxidative stress. In addition, Cor contributed to improving SIRT1 and AMPK expression, inhibited reactive oxygen species and oxidative stress, and elevated autophagy in high-glucose-treated podocytes. Thus, Cor might be a potential therapeutic agent for the treatment and clinical management of DN.