©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Diabetes. Jul 15, 2024; 15(7): 1430-1447
Published online Jul 15, 2024. doi: 10.4239/wjd.v15.i7.1430
Published online Jul 15, 2024. doi: 10.4239/wjd.v15.i7.1430
Insulin resistance as the molecular link between diabetes and Alzheimer's disease
Mona Mohamed Ibrahim Abdalla, Department of Human Biology, School of Medicine, International Medical University, Bukit Jalil 57000, Kuala Lumpur, Malaysia
Author contributions: Abdalla MMI designed the research, searched the databases, and wrote the paper.
Conflict-of-interest statement: The author has nothing to disclose.
Corresponding author: Mona Mohamed Ibrahim Abdalla, MSc, PhD, Senior Lecturer, Department of Human Biology, School of Medicine, International Medical University, No. 126 Jln Jalil Perkasa 19, Bukit Jalil 57000, Kuala Lumpur, Malaysia. monamohamed@imu.edu.my
Received: February 14, 2024
Revised: April 8, 2024
Accepted: May 6, 2024
Published online: July 15, 2024
Processing time: 144 Days and 18.7 Hours
Revised: April 8, 2024
Accepted: May 6, 2024
Published online: July 15, 2024
Processing time: 144 Days and 18.7 Hours
Core Tip
Core Tip: Insulin resistance (IR), commonly associated with type 2 diabetes, is a crucial factor linking diabetes mellitus to Alzheimer's disease (AD). While insulin is primarily known for regulating blood sugar, it also plays a significant role in brain health. Dysfunctional insulin signaling, characteristic of IR, adversely impacts brain functions and is implicated in the development of AD's defining features, such as beta-amyloid plaques and tau protein tangles. Understanding and addressing IR early could offer new treatment strategies for AD, highlighting the importance of continued research in this interdisciplinary field.