Remission of type 2 diabetes mellitus

doi:10.4239/wjd.v15.i7.1384

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World Journal of Diabetes

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1948-9358

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Diabetes. Jul 15, 2024; 15(7): 1384-1389
Published online Jul 15, 2024. doi: 10.4239/wjd.v15.i7.1384

Remission of type 2 diabetes mellitus

Afif Nakhleh, Elya Halfin, Naim Shehadeh

Afif Nakhleh, Naim Shehadeh, Institute of Endocrinology, Diabetes and Metabolism, Rambam Health Care Campus, Haifa 3109601, Israel

Afif Nakhleh, Elya Halfin, Naim Shehadeh, Diabetes and Endocrinology Clinic, Maccabi Healthcare Services, Haifa 3299001, Israel

Afif Nakhleh, Naim Shehadeh, The Azrieli Faculty of Medicine, Bar-Ilan University, Safed 1311502, Israel

Author contributions: Nakhleh A drafted the manuscript; Nakhleh A, Halfin E, and Shehadeh N edited and approved the final version of the manuscript.

Conflict-of-interest statement: The authors declare that there are no conflicts of interest.

Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/

Corresponding author: Afif Nakhleh, MD, Doctor, Institute of Endocrinology, Diabetes and Metabolism, Rambam Health Care Campus, 8 Haaliya Hashniya Street, Haifa 3109601, Israel. anakhleh@gmail.com

Received: December 30, 2023
Revised: April 13, 2024
Accepted: April 28, 2024
Published online: July 15, 2024
Processing time: 190 Days and 13.7 Hours

Core Tip

Core Tip: The rise in type 2 diabetes mellitus (T2DM) parallels the obesity epidemic. Notably, significant weight loss can induce remission, with hemoglobin levels below 6.5% for three months without medication. Herein we present the recent data on a variety of approaches, including lifestyle interventions, glucose-lowering and weight management medications and metabolic surgery that hold promise for inducing T2DM remission.